| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 17 | 17 | 7 | 5 | 3.08 | .275 | 1.12 | 7.3 | 2.9 | 8.9 | 134.1 | 108 | 51 | 46 | 14 | 43 | 132 | 5 | 0 | 0 | 0 | 12 | 2 | 3 | 3.40 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 17 | 17 | 7 | 4 | 4.70 | .339 | 1.52 | 8.5 | 5.2 | 8.7 | 107.1 | 101 | 57 | 56 | 14 | 62 | 103 | 1 | 0 | 0 | 0 | 9 | 2 | 0 | 4.57 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 16 | 16 | 7 | 4 | 3.32 | .275 | 1.11 | 7.2 | 2.7 | 4.5 | 122.0 | 98 | 46 | 45 | 11 | 37 | 61 | 5 | 0 | 0 | 1 | 10 | 4 | 2 | 4.18 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 16 | 16 | 8 | 5 | 4.59 | .301 | 1.28 | 9.2 | 2.4 | 5.3 | 113.2 | 115 | 60 | 58 | 14 | 30 | 66 | 7 | 0 | 0 | 0 | 7 | 2 | 1 | 4.29 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 16 | 16 | 4 | 3 | 5.21 | .348 | 1.59 | 8.8 | 5.5 | 8.1 | 95.0 | 93 | 59 | 55 | 7 | 58 | 86 | 0 | 0 | 0 | 0 | 7 | 1 | 7 | 4.01 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 17 | 0 | 1 | 4 | 4.66 | .383 | 1.86 | 9.5 | 7.6 | 7.6 | 19.1 | 20 | 11 | 10 | 2 | 16 | 16 | 0 | 4 | 2 | 0 | 0 | 0 | 1 | 5.21 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 19 | 0 | 5 | 0 | 1.45 | .188 | 0.70 | 4.0 | 2.5 | 6.0 | 18.2 | 8 | 4 | 3 | 2 | 5 | 12 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 3.94 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 3 | 0 | 0 | 0 | 2.45 | .267 | 1.09 | 9.0 | 3.0 | 12.0 | 3.2 | 3 | 1 | 1 | 0 | 1 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.33 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 5 | 0 | 0 | 0 | 2.70 | .375 | 1.80 | 9.0 | 9.0 | 3.0 | 3.1 | 3 | 4 | 1 | 2 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14.00 |