| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 20 | 20 | 12 | 6 | 3.54 | .281 | 1.13 | 6.9 | 3.3 | 7.6 | 139.2 | 107 | 57 | 55 | 14 | 51 | 118 | 4 | 0 | 0 | 1 | 14 | 6 | 4 | 3.84 |
| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 95 | 18 | 18 | 9 | 3 | 3.80 | .306 | 1.31 | 7.6 | 4.2 | 9.8 | 111.1 | 94 | 48 | 47 | 8 | 52 | 121 | 1 | 0 | 0 | 1 | 13 | 1 | 3 | 3.19 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 38 | 0 | 1 | 3 | 3.79 | .248 | 0.99 | 6.8 | 2.3 | 9.5 | 40.1 | 30 | 17 | 17 | 6 | 10 | 42 | 0 | 27 | 3 | 0 | 0 | 0 | 2 | 3.60 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 33 | 0 | 1 | 1 | 4.78 | .319 | 1.41 | 8.7 | 3.9 | 7.3 | 32.0 | 31 | 18 | 17 | 4 | 14 | 26 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 4.31 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 36 | 0 | 1 | 2 | 3.77 | .303 | 1.28 | 6.9 | 4.6 | 9.0 | 43.0 | 33 | 19 | 18 | 7 | 22 | 43 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.72 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 86 | 30 | 0 | 1 | 4 | 8.23 | .374 | 1.79 | 11.0 | 5.3 | 10.7 | 27.1 | 33 | 27 | 25 | 5 | 16 | 32 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 4.81 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 20 | 0 | 1 | 0 | 5.14 | .337 | 1.52 | 10.3 | 3.4 | 9.0 | 21.0 | 24 | 12 | 12 | 2 | 8 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.38 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 70 | 4 | 0 | 0 | 0 | 4.40 | .271 | 1.12 | 8.4 | 1.9 | 7.1 | 14.1 | 13 | 8 | 7 | 2 | 3 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.93 |