| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 18 | 18 | 6 | 8 | 3.30 | .254 | 0.99 | 6.5 | 2.4 | 9.0 | 122.2 | 88 | 46 | 45 | 14 | 33 | 122 | 3 | 0 | 0 | 1 | 11 | 4 | 0 | 3.40 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 17 | 17 | 10 | 5 | 3.87 | .296 | 1.25 | 8.9 | 2.4 | 7.7 | 104.2 | 103 | 47 | 45 | 12 | 28 | 89 | 1 | 0 | 0 | 0 | 11 | 1 | 0 | 3.63 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 16 | 16 | 7 | 4 | 3.28 | .276 | 1.14 | 8.1 | 2.2 | 7.3 | 98.2 | 88 | 41 | 36 | 10 | 24 | 80 | 1 | 0 | 0 | 0 | 10 | 1 | 1 | 3.46 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 78 | 16 | 16 | 6 | 8 | 3.83 | .271 | 1.08 | 7.3 | 2.5 | 5.2 | 103.1 | 83 | 44 | 44 | 7 | 29 | 59 | 5 | 0 | 0 | 1 | 10 | 3 | 3 | 3.67 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 41 | 15 | 15 | 6 | 2 | 4.99 | .322 | 1.39 | 9.2 | 3.3 | 7.9 | 92.0 | 94 | 52 | 51 | 12 | 34 | 81 | 2 | 0 | 0 | 0 | 7 | 3 | 3 | 4.14 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 41 | 0 | 1 | 5 | 4.20 | .289 | 1.22 | 7.6 | 3.4 | 8.0 | 45.0 | 38 | 21 | 21 | 2 | 17 | 40 | 0 | 7 | 2 | 0 | 0 | 0 | 2 | 2.93 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 22 | 0 | 4 | 0 | 5.40 | .307 | 1.33 | 8.2 | 3.9 | 9.8 | 23.1 | 21 | 14 | 14 | 5 | 10 | 25 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 4.96 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 18 | 0 | 3 | 0 | 1.69 | .264 | 1.08 | 6.4 | 3.4 | 5.1 | 21.1 | 15 | 4 | 4 | 0 | 8 | 12 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 49 | 14 | 0 | 3 | 0 | 3.28 | .323 | 1.43 | 10.5 | 2.6 | 6.2 | 35.2 | 41 | 13 | 13 | 3 | 10 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.60 |