| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 98 | 32 | 32 | 11 | 15 | 4.49 | .297 | 1.24 | 8.9 | 2.3 | 8.9 | 214.2 | 211 | 109 | 107 | 29 | 55 | 211 | 1 | 0 | 0 | 0 | 16 | 6 | 4 | 3.64 |
| SP | Hudson, D.Hudson, Daniel # >> | 23 | 2010 | R | 72 | 31 | 31 | 9 | 15 | 4.78 | .301 | 1.27 | 8.4 | 3.0 | 6.5 | 179.0 | 167 | 100 | 95 | 27 | 60 | 129 | 1 | 0 | 0 | 1 | 17 | 4 | 2 | 4.59 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 29 | 29 | 7 | 15 | 6.19 | .349 | 1.59 | 11.1 | 3.2 | 10.1 | 173.0 | 213 | 125 | 119 | 49 | 62 | 195 | 0 | 0 | 0 | 0 | 9 | 3 | 7 | 5.55 |
| CL | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 61 | 0 | 3 | 9 | 3.69 | .322 | 1.39 | 5.8 | 6.8 | 9.1 | 61.0 | 39 | 28 | 25 | 7 | 46 | 62 | 0 | 31 | 4 | 0 | 0 | 2 | 1 | 4.82 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 88 | 65 | 0 | 3 | 6 | 4.32 | .324 | 1.41 | 8.9 | 4.0 | 9.7 | 66.2 | 65 | 34 | 32 | 10 | 29 | 71 | 0 | 1 | 8 | 0 | 0 | 2 | 5 | 4.23 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 73 | 78 | 0 | 1 | 1 | 4.41 | .327 | 1.44 | 8.2 | 4.9 | 12.2 | 79.2 | 72 | 40 | 39 | 10 | 43 | 107 | 0 | 3 | 1 | 0 | 0 | 1 | 4 | 3.61 |
| RP | Pagan, E.Pagan, Emilio # >> | 28 | 2019 | R | 72 | 53 | 0 | 4 | 2 | 5.37 | .325 | 1.40 | 9.5 | 3.1 | 11.6 | 52.0 | 55 | 32 | 31 | 13 | 18 | 67 | 0 | 0 | 1 | 0 | 0 | 2 | 5 | 4.83 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 30 | 0 | 2 | 1 | 3.09 | .286 | 1.20 | 6.2 | 4.6 | 8.2 | 35.0 | 24 | 14 | 12 | 1 | 18 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.09 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 65 | 23 | 0 | 1 | 0 | 5.46 | .333 | 1.46 | 10.1 | 3.0 | 6.5 | 89.0 | 100 | 54 | 54 | 16 | 30 | 64 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 5.01 |