| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 19 | 19 | 2 | 15 | 5.43 | .343 | 1.54 | 10.2 | 3.6 | 8.6 | 126.0 | 143 | 80 | 76 | 22 | 51 | 120 | 3 | 0 | 0 | 0 | 8 | 3 | 5 | 4.65 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 70 | 18 | 18 | 6 | 5 | 5.46 | .319 | 1.37 | 8.9 | 3.5 | 7.1 | 113.2 | 112 | 69 | 69 | 20 | 44 | 89 | 0 | 0 | 0 | 0 | 8 | 4 | 3 | 5.00 |
| SP | DeLeon, J.DeLeon, Jose >> | 29 | 1989 | R | 58 | 18 | 18 | 3 | 11 | 5.68 | .333 | 1.45 | 9.3 | 3.7 | 7.7 | 111.0 | 115 | 80 | 70 | 26 | 46 | 95 | 0 | 0 | 0 | 0 | 8 | 5 | 1 | 5.71 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 57 | 18 | 18 | 4 | 11 | 5.61 | .354 | 1.62 | 9.8 | 4.8 | 9.7 | 122.0 | 133 | 78 | 76 | 21 | 65 | 131 | 2 | 0 | 0 | 0 | 6 | 3 | 1 | 4.76 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 51 | 0 | 2 | 4 | 4.39 | .354 | 1.61 | 9.8 | 4.8 | 8.2 | 65.2 | 71 | 40 | 32 | 6 | 35 | 59 | 0 | 5 | 4 | 0 | 0 | 2 | 2 | 4.09 |
| RP | Williams, D.Williams, Devin † >> | 28 | 2023 | R | 70 | 44 | 0 | 6 | 0 | 2.24 | .302 | 1.26 | 5.7 | 5.7 | 9.7 | 52.1 | 33 | 13 | 13 | 4 | 33 | 56 | 0 | 6 | 2 | 0 | 0 | 2 | 1 | 3.87 |