| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 98 | 19 | 19 | 9 | 8 | 3.76 | .295 | 1.23 | 8.5 | 2.6 | 9.1 | 136.1 | 129 | 57 | 57 | 21 | 39 | 137 | 2 | 0 | 0 | 1 | 11 | 3 | 3 | 3.92 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 18 | 18 | 7 | 7 | 6.04 | .345 | 1.56 | 10.5 | 3.6 | 8.7 | 101.1 | 118 | 68 | 68 | 24 | 40 | 98 | 1 | 0 | 0 | 0 | 8 | 2 | 0 | 5.40 |
| SP | Guidry, R.Guidry, Ron † >> | 28 | 1978 | L | 81 | 18 | 18 | 11 | 5 | 4.20 | .318 | 1.38 | 9.5 | 2.9 | 5.5 | 122.0 | 129 | 57 | 57 | 16 | 39 | 75 | 5 | 0 | 0 | 2 | 9 | 3 | 5 | 4.51 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 82 | 18 | 18 | 9 | 4 | 3.72 | .263 | 1.04 | 7.1 | 2.3 | 8.1 | 116.0 | 91 | 49 | 48 | 22 | 30 | 105 | 1 | 0 | 0 | 1 | 11 | 3 | 2 | 4.51 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 42 | 0 | 3 | 0 | 1.13 | .220 | 0.81 | 5.2 | 2.1 | 9.5 | 55.2 | 32 | 7 | 7 | 2 | 13 | 58 | 0 | 8 | 4 | 0 | 0 | 2 | 0 | 2.18 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 85 | 27 | 0 | 3 | 2 | 2.78 | .230 | 0.87 | 6.5 | 1.4 | 7.9 | 32.1 | 23 | 10 | 10 | 4 | 5 | 28 | 0 | 6 | 2 | 0 | 0 | 1 | 0 | 3.44 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 20 | 0 | 0 | 1 | 1.44 | .202 | 0.76 | 5.4 | 1.4 | 9.0 | 25.0 | 15 | 5 | 4 | 1 | 4 | 25 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 11 | 0 | 1 | 2 | 9.00 | .419 | 2.17 | 16.5 | 3.0 | 9.0 | 6.0 | 11 | 6 | 6 | 1 | 2 | 6 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.17 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 7 | 0 | 1 | 0 | 5.59 | .293 | 1.24 | 6.0 | 6.0 | 10.0 | 9.2 | 6 | 6 | 6 | 2 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.67 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 11 | 0 | 0 | 0 | 3.55 | .255 | 1.03 | 6.8 | 3.0 | 9.0 | 12.2 | 9 | 5 | 5 | 2 | 4 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.17 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 76 | 15 | 0 | 3 | 0 | 3.00 | .258 | 1.01 | 7.5 | 1.6 | 7.0 | 72.0 | 60 | 26 | 24 | 9 | 13 | 56 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3.69 |