| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 95 | 32 | 32 | 15 | 11 | 2.90 | .261 | 1.05 | 7.0 | 2.5 | 8.6 | 245.1 | 190 | 85 | 79 | 26 | 67 | 233 | 7 | 0 | 0 | 4 | 21 | 3 | 1 | 3.33 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 31 | 31 | 15 | 10 | 3.38 | .265 | 1.05 | 7.4 | 2.1 | 9.1 | 236.2 | 193 | 89 | 89 | 39 | 56 | 239 | 6 | 0 | 0 | 2 | 17 | 7 | 8 | 3.92 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 83 | 31 | 31 | 12 | 13 | 4.74 | .317 | 1.35 | 9.1 | 3.1 | 6.2 | 216.2 | 218 | 119 | 114 | 23 | 74 | 149 | 12 | 0 | 0 | 1 | 13 | 9 | 6 | 4.16 |
| SP | Gooden, D.Gooden, Dwight # >> | 21 | 1985 | R | 76 | 31 | 31 | 15 | 12 | 4.28 | .287 | 1.18 | 7.6 | 3.1 | 7.4 | 241.2 | 203 | 116 | 115 | 32 | 83 | 197 | 7 | 0 | 0 | 0 | 14 | 6 | 7 | 4.20 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 29 | 29 | 13 | 8 | 3.07 | .261 | 1.00 | 5.6 | 3.4 | 8.8 | 196.1 | 122 | 69 | 67 | 22 | 74 | 191 | 1 | 0 | 0 | 0 | 19 | 12 | 1 | 3.83 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 96 | 80 | 0 | 4 | 4 | 2.82 | .266 | 1.04 | 7.1 | 2.3 | 10.3 | 89.1 | 70 | 28 | 28 | 9 | 23 | 102 | 0 | 16 | 5 | 0 | 0 | 4 | 1 | 2.93 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 91 | 47 | 0 | 6 | 4 | 1.56 | .249 | 0.98 | 5.4 | 3.4 | 11.0 | 63.1 | 38 | 11 | 11 | 5 | 24 | 77 | 0 | 7 | 4 | 0 | 0 | 1 | 0 | 2.78 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 23 | 0 | 0 | 2 | 2.84 | .255 | 0.99 | 7.2 | 1.8 | 8.3 | 25.1 | 20 | 8 | 8 | 3 | 5 | 23 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 3.44 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 11 | 0 | 4 | 0 | 0.73 | .140 | 0.49 | 3.0 | 1.5 | 3.0 | 12.1 | 4 | 1 | 1 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.83 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 62 | 12 | 0 | 0 | 2 | 3.86 | .250 | 0.86 | 5.8 | 1.9 | 7.7 | 14.0 | 9 | 6 | 6 | 3 | 3 | 12 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 5.14 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 66 | 14 | 0 | 1 | 3 | 5.74 | .343 | 1.57 | 11.3 | 2.8 | 5.0 | 58.0 | 73 | 37 | 37 | 10 | 18 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.07 |