| SP | Scott, M.Scott, Mike † >> | 31 | 1986 | R | 92 | 24 | 24 | 10 | 8 | 3.63 | .304 | 1.31 | 7.9 | 3.8 | 8.9 | 166.0 | 146 | 67 | 67 | 22 | 71 | 164 | 7 | 0 | 0 | 3 | 12 | 1 | 1 | 4.05 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 23 | 23 | 9 | 10 | 4.38 | .285 | 1.19 | 8.6 | 2.1 | 6.4 | 141.2 | 135 | 71 | 69 | 16 | 33 | 100 | 4 | 0 | 0 | 1 | 14 | 1 | 2 | 3.78 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 82 | 23 | 23 | 10 | 4 | 3.76 | .268 | 1.08 | 6.3 | 3.4 | 9.5 | 139.0 | 98 | 60 | 58 | 19 | 52 | 146 | 1 | 0 | 0 | 0 | 13 | 3 | 0 | 3.86 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 76 | 21 | 21 | 8 | 8 | 6.77 | .373 | 1.78 | 12.6 | 3.5 | 9.9 | 90.1 | 126 | 71 | 68 | 15 | 35 | 99 | 0 | 0 | 0 | 0 | 7 | 0 | 1 | 4.13 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 49 | 0 | 5 | 3 | 2.76 | .265 | 1.06 | 5.3 | 4.2 | 10.8 | 49.0 | 29 | 15 | 15 | 6 | 23 | 59 | 0 | 26 | 1 | 0 | 0 | 1 | 0 | 3.65 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 81 | 59 | 0 | 5 | 3 | 2.59 | .282 | 1.15 | 6.4 | 3.9 | 9.2 | 73.0 | 52 | 21 | 21 | 7 | 32 | 75 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 3.59 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 70 | 48 | 0 | 6 | 1 | 2.34 | .275 | 1.14 | 5.9 | 4.4 | 8.9 | 61.2 | 40 | 16 | 16 | 4 | 30 | 60 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 3.36 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 37 | 0 | 1 | 2 | 4.89 | .318 | 1.37 | 8.3 | 4.3 | 11.6 | 38.2 | 35 | 22 | 21 | 8 | 18 | 49 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 4.66 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 33 | 0 | 1 | 0 | 1.91 | .257 | 1.01 | 4.4 | 4.9 | 10.7 | 37.2 | 18 | 8 | 8 | 2 | 20 | 44 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.03 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 69 | 27 | 0 | 0 | 1 | 4.68 | .359 | 1.65 | 9.3 | 5.9 | 11.3 | 32.2 | 33 | 18 | 17 | 3 | 21 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.78 |