| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 93 | 25 | 25 | 5 | 11 | 4.25 | .347 | 1.56 | 9.2 | 4.8 | 9.1 | 161.0 | 165 | 76 | 76 | 17 | 86 | 162 | 1 | 0 | 0 | 0 | 14 | 6 | 0 | 4.07 |
| SP | Hendricks, K.Hendricks, Kyle # >> | 26 | 2016 | R | 73 | 24 | 24 | 6 | 13 | 4.79 | .300 | 1.27 | 8.8 | 2.6 | 7.1 | 148.1 | 145 | 80 | 79 | 22 | 43 | 117 | 2 | 0 | 0 | 1 | 11 | 3 | 3 | 4.28 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 55 | 24 | 24 | 3 | 11 | 4.68 | .358 | 1.64 | 9.8 | 4.9 | 9.6 | 148.0 | 161 | 78 | 77 | 19 | 81 | 158 | 0 | 0 | 0 | 0 | 12 | 6 | 6 | 4.30 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 51 | 23 | 23 | 2 | 13 | 6.56 | .343 | 1.55 | 11.1 | 2.8 | 5.7 | 130.1 | 161 | 95 | 95 | 29 | 41 | 82 | 0 | 0 | 0 | 0 | 6 | 2 | 6 | 5.63 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 94 | 66 | 0 | 1 | 7 | 4.18 | .349 | 1.61 | 7.6 | 6.9 | 10.7 | 79.2 | 67 | 38 | 37 | 8 | 61 | 94 | 0 | 5 | 6 | 0 | 0 | 0 | 7 | 4.25 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 73 | 62 | 0 | 7 | 6 | 5.63 | .347 | 1.57 | 7.0 | 7.1 | 10.8 | 72.0 | 56 | 45 | 45 | 10 | 57 | 86 | 0 | 3 | 2 | 0 | 0 | 2 | 4 | 4.88 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 59 | 63 | 0 | 3 | 2 | 2.71 | .287 | 1.21 | 6.2 | 4.7 | 9.7 | 73.0 | 50 | 22 | 22 | 8 | 38 | 79 | 0 | 12 | 3 | 0 | 0 | 0 | 0 | 3.82 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 48 | 35 | 0 | 1 | 1 | 2.36 | .280 | 1.17 | 7.3 | 3.2 | 11.6 | 42.0 | 34 | 11 | 11 | 6 | 15 | 54 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 3.36 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 40 | 34 | 0 | 2 | 0 | 2.62 | .322 | 1.37 | 8.5 | 4.0 | 9.5 | 34.1 | 32 | 10 | 10 | 2 | 15 | 36 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 3.15 |
| SP | Wainwright, A.Wainwright, Adam >> | 29 | 2010 | R | 43 | 19 | 0 | 2 | 4 | 5.09 | .317 | 1.39 | 10.2 | 2.3 | 7.0 | 23.0 | 26 | 13 | 13 | 5 | 6 | 18 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.04 |