| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 39 | 39 | 13 | 12 | 2.91 | .263 | 1.05 | 6.9 | 2.6 | 10.0 | 268.2 | 205 | 88 | 87 | 36 | 76 | 299 | 1 | 0 | 0 | 0 | 26 | 7 | 0 | 3.44 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 38 | 38 | 13 | 18 | 6.27 | .338 | 1.52 | 9.7 | 4.0 | 8.4 | 254.0 | 273 | 180 | 177 | 50 | 112 | 238 | 3 | 0 | 0 | 0 | 12 | 4 | 5 | 5.06 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 75 | 35 | 35 | 15 | 16 | 4.41 | .327 | 1.44 | 8.9 | 4.0 | 6.5 | 255.1 | 253 | 131 | 125 | 39 | 114 | 183 | 4 | 0 | 0 | 1 | 18 | 6 | 7 | 4.96 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 100 | 0 | 8 | 4 | 3.66 | .306 | 1.29 | 7.1 | 4.5 | 10.7 | 125.1 | 99 | 53 | 51 | 17 | 63 | 148 | 0 | 6 | 6 | 0 | 0 | 4 | 11 | 4.01 |
| RP | Betances, D.Betances, Dellin † >> | 26 | 2014 | R | 92 | 88 | 0 | 12 | 4 | 2.62 | .272 | 1.09 | 6.8 | 3.1 | 10.4 | 106.1 | 80 | 33 | 31 | 13 | 36 | 122 | 0 | 14 | 6 | 0 | 0 | 3 | 2 | 3.40 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 54 | 0 | 5 | 5 | 2.34 | .288 | 1.22 | 6.9 | 4.1 | 8.0 | 61.2 | 47 | 16 | 16 | 3 | 28 | 54 | 0 | 11 | 0 | 0 | 0 | 0 | 0 | 3.25 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 72 | 38 | 0 | 2 | 2 | 2.41 | .255 | 1.00 | 5.3 | 3.7 | 9.7 | 41.0 | 24 | 11 | 11 | 1 | 17 | 44 | 0 | 7 | 0 | 0 | 0 | 1 | 4 | 2.49 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 26 | 0 | 1 | 2 | 7.24 | .388 | 1.90 | 13.0 | 4.3 | 9.0 | 27.1 | 39 | 22 | 22 | 6 | 13 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.33 |