| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 95 | 34 | 34 | 17 | 12 | 4.41 | .323 | 1.40 | 9.0 | 3.6 | 9.0 | 224.2 | 224 | 113 | 110 | 22 | 90 | 223 | 3 | 0 | 0 | 1 | 20 | 8 | 4 | 3.60 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 33 | 33 | 5 | 22 | 7.10 | .364 | 1.68 | 10.7 | 4.5 | 8.3 | 185.0 | 219 | 149 | 146 | 39 | 92 | 171 | 1 | 0 | 0 | 0 | 9 | 6 | 11 | 5.48 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 32 | 32 | 7 | 9 | 5.05 | .315 | 1.34 | 8.8 | 3.3 | 10.2 | 144.1 | 141 | 83 | 81 | 21 | 53 | 163 | 0 | 0 | 0 | 0 | 4 | 5 | 9 | 3.84 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 29 | 29 | 13 | 11 | 4.46 | .310 | 1.31 | 9.3 | 2.5 | 9.1 | 189.2 | 196 | 98 | 94 | 33 | 53 | 192 | 4 | 0 | 0 | 2 | 14 | 7 | 4 | 4.19 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 81 | 88 | 0 | 4 | 1 | 3.91 | .289 | 1.18 | 7.2 | 3.4 | 10.0 | 92.0 | 74 | 41 | 40 | 11 | 35 | 102 | 0 | 3 | 3 | 0 | 0 | 3 | 4 | 3.58 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 76 | 0 | 0 | 2 | 4.58 | .310 | 1.32 | 7.9 | 4.1 | 9.9 | 72.2 | 63 | 39 | 37 | 8 | 33 | 79 | 0 | 1 | 0 | 0 | 0 | 2 | 3 | 3.71 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 65 | 64 | 0 | 9 | 2 | 5.63 | .351 | 1.61 | 9.1 | 5.4 | 8.6 | 86.1 | 87 | 56 | 54 | 13 | 52 | 82 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 4.91 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 89 | 9 | 0 | 2 | 1 | 4.02 | .309 | 1.34 | 10.8 | 1.8 | 9.6 | 15.2 | 18 | 10 | 7 | 2 | 3 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.20 |