| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 34 | 34 | 13 | 10 | 4.04 | .299 | 1.26 | 7.3 | 4.1 | 9.5 | 211.2 | 170 | 98 | 95 | 29 | 97 | 222 | 2 | 0 | 0 | 2 | 17 | 4 | 5 | 4.12 |
| SP | Sutton, D.Sutton, Don † >> | 27 | 1972 | R | 85 | 33 | 33 | 13 | 11 | 4.72 | .303 | 1.30 | 8.7 | 3.0 | 6.6 | 213.2 | 205 | 116 | 112 | 27 | 72 | 156 | 8 | 0 | 0 | 1 | 17 | 1 | 8 | 4.21 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 33 | 33 | 3 | 13 | 5.24 | .300 | 1.27 | 8.3 | 3.1 | 10.3 | 149.1 | 137 | 90 | 87 | 31 | 52 | 170 | 0 | 0 | 0 | 0 | 1 | 3 | 6 | 4.53 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 88 | 30 | 30 | 11 | 7 | 4.22 | .291 | 1.19 | 7.9 | 2.7 | 5.0 | 162.0 | 143 | 80 | 76 | 22 | 49 | 90 | 0 | 0 | 0 | 0 | 11 | 7 | 2 | 4.69 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 64 | 0 | 5 | 6 | 1.54 | .236 | 0.91 | 5.1 | 3.1 | 9.8 | 70.0 | 40 | 16 | 12 | 2 | 24 | 76 | 0 | 37 | 1 | 0 | 0 | 1 | 1 | 2.27 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 88 | 45 | 0 | 1 | 3 | 2.87 | .263 | 1.07 | 6.6 | 3.1 | 7.6 | 53.1 | 39 | 17 | 17 | 6 | 18 | 45 | 0 | 10 | 3 | 0 | 0 | 0 | 2 | 3.79 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 71 | 0 | 3 | 5 | 4.59 | .294 | 1.23 | 8.1 | 3.0 | 9.1 | 86.1 | 77 | 46 | 44 | 18 | 29 | 87 | 0 | 1 | 4 | 0 | 0 | 2 | 0 | 4.78 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 62 | 0 | 8 | 4 | 3.88 | .318 | 1.38 | 6.9 | 5.5 | 8.4 | 65.0 | 50 | 28 | 28 | 11 | 40 | 61 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 5.22 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 80 | 46 | 0 | 3 | 0 | 2.38 | .281 | 1.15 | 6.5 | 3.9 | 6.6 | 53.0 | 38 | 17 | 14 | 3 | 23 | 39 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 3.62 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 75 | 37 | 0 | 2 | 1 | 4.62 | .320 | 1.41 | 10.4 | 2.3 | 7.4 | 39.0 | 45 | 21 | 20 | 4 | 10 | 32 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.46 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 69 | 17 | 1 | 4 | 2 | 4.15 | .310 | 1.31 | 8.3 | 3.5 | 5.0 | 82.1 | 76 | 41 | 38 | 14 | 32 | 46 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 5.38 |