| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 34 | 34 | 16 | 9 | 2.69 | .254 | 1.01 | 6.5 | 2.6 | 11.3 | 227.2 | 164 | 78 | 68 | 31 | 66 | 285 | 1 | 0 | 0 | 1 | 24 | 2 | 0 | 3.16 |
| SP | McClanahan, S.McClanahan, Shane # >> | 25 | 2022 | L | 89 | 33 | 33 | 14 | 10 | 4.13 | .295 | 1.24 | 8.4 | 2.8 | 9.1 | 202.2 | 189 | 101 | 93 | 36 | 63 | 204 | 0 | 0 | 0 | 0 | 20 | 3 | 3 | 4.28 |
| SP | Buehler, W.Buehler, Walker >> | 23 | 2018 | R | 85 | 32 | 32 | 7 | 11 | 6.23 | .369 | 1.73 | 10.9 | 4.7 | 9.5 | 169.0 | 205 | 118 | 117 | 34 | 88 | 178 | 0 | 0 | 0 | 0 | 7 | 4 | 2 | 5.14 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 53 | 31 | 31 | 16 | 6 | 3.85 | .310 | 1.33 | 7.1 | 4.9 | 8.0 | 191.2 | 151 | 92 | 82 | 23 | 103 | 169 | 0 | 0 | 0 | 0 | 17 | 4 | 2 | 4.48 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 89 | 0 | 9 | 2 | 4.72 | .257 | 1.03 | 6.8 | 2.5 | 8.8 | 110.2 | 83 | 58 | 58 | 17 | 31 | 107 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 3.94 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 73 | 0 | 5 | 3 | 4.50 | .321 | 1.42 | 8.3 | 4.5 | 12.6 | 76.0 | 70 | 41 | 38 | 14 | 38 | 106 | 0 | 0 | 3 | 0 | 0 | 0 | 5 | 4.11 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 65 | 0 | 8 | 10 | 3.25 | .253 | 1.02 | 6.4 | 2.8 | 10.3 | 74.2 | 53 | 31 | 27 | 9 | 23 | 85 | 0 | 38 | 7 | 0 | 0 | 0 | 0 | 3.22 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 53 | 0 | 1 | 1 | 3.16 | .285 | 1.19 | 6.6 | 4.1 | 10.6 | 57.0 | 42 | 23 | 20 | 7 | 26 | 67 | 0 | 4 | 5 | 0 | 0 | 0 | 0 | 3.61 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 70 | 2 | 0 | 2 | 0 | 4.50 | .368 | 1.75 | 6.8 | 9.0 | 6.8 | 4.0 | 3 | 3 | 2 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.50 |