| SP | Skubal, T.Skubal, Tarik $$ >> | 28 | 2025 | L | 100 | 25 | 25 | 12 | 5 | 3.81 | .287 | 1.19 | 8.3 | 2.4 | 10.7 | 163.0 | 150 | 74 | 69 | 15 | 44 | 194 | 0 | 0 | 0 | 0 | 15 | 3 | 1 | 2.68 |
| SP | Peralta, F.Peralta, Freddy † >> | 29 | 2025 | R | 89 | 24 | 24 | 12 | 3 | 2.84 | .271 | 1.07 | 7.0 | 2.7 | 9.6 | 142.2 | 110 | 47 | 45 | 20 | 43 | 152 | 1 | 0 | 0 | 1 | 12 | 6 | 3 | 3.73 |
| SP | Horton, C.Horton, Cade # >> | 23 | 2025 | R | 79 | 24 | 24 | 8 | 6 | 5.06 | .299 | 1.26 | 9.0 | 2.4 | 7.9 | 126.1 | 126 | 75 | 71 | 25 | 33 | 111 | 0 | 0 | 0 | 0 | 7 | 3 | 1 | 4.67 |
| CL | Hader, J.Hader, Josh † $ >> | 31 | 2025 | L | 100 | 60 | 0 | 5 | 3 | 2.87 | .280 | 1.13 | 6.2 | 4.1 | 10.3 | 62.2 | 43 | 20 | 20 | 11 | 28 | 71 | 0 | 32 | 4 | 0 | 0 | 2 | 1 | 4.47 |
| SU | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 90 | 58 | 0 | 7 | 2 | 2.55 | .296 | 1.20 | 7.2 | 3.7 | 11.1 | 70.2 | 56 | 20 | 20 | 6 | 29 | 86 | 0 | 1 | 4 | 0 | 0 | 4 | 1 | 3.07 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 82 | 71 | 0 | 6 | 3 | 3.62 | .289 | 1.20 | 8.0 | 2.8 | 10.3 | 87.0 | 77 | 35 | 35 | 15 | 27 | 100 | 0 | 2 | 2 | 0 | 0 | 2 | 3 | 3.94 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 66 | 0 | 3 | 0 | 3.19 | .307 | 1.27 | 7.3 | 4.1 | 7.2 | 79.0 | 64 | 28 | 28 | 14 | 36 | 63 | 0 | 6 | 2 | 0 | 0 | 5 | 1 | 5.27 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 76 | 55 | 0 | 3 | 2 | 3.43 | .259 | 1.04 | 6.5 | 2.9 | 9.0 | 65.2 | 47 | 26 | 25 | 6 | 21 | 65 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 3.22 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 70 | 44 | 0 | 3 | 1 | 4.76 | .349 | 1.59 | 10.6 | 3.8 | 8.4 | 45.1 | 53 | 27 | 24 | 7 | 19 | 42 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.49 |