| SP | Eovaldi, N.Eovaldi, Nathan † >> | 35 | 2025 | R | 98 | 23 | 23 | 11 | 8 | 3.49 | .286 | 1.17 | 8.3 | 2.3 | 8.0 | 152.0 | 140 | 69 | 59 | 16 | 38 | 135 | 0 | 0 | 0 | 0 | 14 | 5 | 5 | 3.44 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 84 | 25 | 25 | 5 | 13 | 5.39 | .349 | 1.57 | 10.9 | 3.2 | 8.0 | 147.0 | 178 | 94 | 88 | 23 | 53 | 131 | 0 | 0 | 0 | 0 | 8 | 5 | 3 | 4.44 |
| SP | Nelson, R.Nelson, Ryne # >> | 27 | 2025 | R | 81 | 22 | 22 | 2 | 7 | 6.14 | .355 | 1.60 | 10.4 | 4.0 | 7.8 | 104.0 | 120 | 75 | 71 | 19 | 46 | 90 | 0 | 0 | 0 | 0 | 2 | 6 | 1 | 5.14 |
| SP | Luzardo, J.Luzardo, Jesus † >> | 27 | 2025 | L | 69 | 24 | 24 | 13 | 9 | 3.37 | .298 | 1.24 | 7.9 | 3.3 | 10.4 | 149.2 | 130 | 56 | 56 | 17 | 55 | 172 | 1 | 0 | 0 | 0 | 16 | 6 | 2 | 3.40 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 67 | 22 | 22 | 5 | 9 | 4.80 | .334 | 1.45 | 10.0 | 3.1 | 7.4 | 129.1 | 143 | 69 | 69 | 19 | 44 | 106 | 0 | 0 | 0 | 0 | 13 | 8 | 1 | 4.48 |
| RP | Raley, B.Raley, Brooks >> | 37 | 2025 | L | 98 | 63 | 0 | 1 | 5 | 3.66 | .283 | 1.19 | 7.7 | 3.0 | 10.0 | 91.0 | 78 | 39 | 37 | 8 | 30 | 101 | 0 | 4 | 5 | 0 | 0 | 0 | 0 | 2.91 |
| RP | Clarke, T.Clarke, Taylor # >> | 32 | 2025 | R | 87 | 64 | 0 | 4 | 4 | 3.83 | .287 | 1.17 | 8.6 | 2.0 | 7.1 | 87.0 | 83 | 41 | 37 | 9 | 19 | 69 | 0 | 7 | 4 | 0 | 0 | 3 | 7 | 3.52 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 77 | 58 | 0 | 3 | 3 | 5.50 | .318 | 1.38 | 9.1 | 3.4 | 9.8 | 68.2 | 69 | 44 | 42 | 11 | 26 | 74 | 0 | 4 | 2 | 0 | 0 | 1 | 1 | 4.12 |
| RP | Phillips, T.Phillips, Tyler >> | 27 | 2025 | R | 56 | 37 | 0 | 4 | 3 | 4.30 | .361 | 1.63 | 11.2 | 3.5 | 7.4 | 46.0 | 57 | 26 | 22 | 5 | 18 | 38 | 0 | 4 | 0 | 0 | 0 | 3 | 5 | 4.13 |
| SP | Wacha, M.Wacha, Michael >> | 33 | 2025 | R | 49 | 7 | 4 | 1 | 2 | 6.57 | .378 | 1.78 | 12.8 | 3.8 | 9.4 | 24.2 | 34 | 22 | 18 | 8 | 10 | 25 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 6.63 |
| SP | Bibee, T.Bibee, Tanner >> | 26 | 2025 | R | 58 | 17 | 1 | 2 | 2 | 7.49 | .392 | 1.93 | 12.8 | 4.9 | 9.0 | 33.2 | 47 | 31 | 28 | 6 | 18 | 33 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 5.00 |