| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 19 | 19 | 3 | 9 | 4.63 | .308 | 1.30 | 9.5 | 2.3 | 7.6 | 130.1 | 137 | 73 | 67 | 17 | 33 | 110 | 1 | 0 | 0 | 0 | 8 | 4 | 2 | 3.86 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 18 | 18 | 2 | 11 | 4.55 | .306 | 1.30 | 8.5 | 3.3 | 8.0 | 122.2 | 115 | 71 | 62 | 21 | 45 | 109 | 2 | 0 | 0 | 0 | 10 | 2 | 3 | 4.61 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 17 | 17 | 8 | 6 | 3.64 | .285 | 1.20 | 7.3 | 3.5 | 9.2 | 118.2 | 96 | 50 | 48 | 14 | 46 | 121 | 1 | 0 | 0 | 0 | 9 | 0 | 3 | 3.66 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 17 | 17 | 9 | 6 | 4.08 | .310 | 1.31 | 9.2 | 2.5 | 3.5 | 117.0 | 120 | 56 | 53 | 11 | 33 | 45 | 2 | 0 | 0 | 1 | 10 | 5 | 4 | 4.43 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 17 | 17 | 5 | 8 | 5.80 | .321 | 1.38 | 9.7 | 2.8 | 6.4 | 108.2 | 116 | 74 | 70 | 16 | 34 | 77 | 7 | 0 | 0 | 1 | 6 | 4 | 3 | 4.56 |
| RP | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 46 | 0 | 8 | 1 | 2.04 | .248 | 0.99 | 5.3 | 3.7 | 8.7 | 61.2 | 36 | 16 | 14 | 2 | 25 | 59 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 2.72 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 20 | 0 | 1 | 1 | 6.19 | .324 | 1.44 | 11.8 | 1.1 | 5.1 | 16.0 | 21 | 11 | 11 | 4 | 2 | 9 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 5.50 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 7 | 0 | 3 | 0 | 7.88 | .351 | 1.63 | 10.1 | 4.5 | 6.8 | 8.0 | 9 | 7 | 7 | 2 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.25 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 5 | 0 | 0 | 0 | 2.84 | .269 | 0.95 | 7.5 | 1.5 | 9.0 | 6.1 | 5 | 2 | 2 | 0 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2.00 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 13 | 0 | 0 | 0 | 6.27 | .333 | 1.45 | 10.0 | 3.5 | 5.0 | 18.2 | 20 | 17 | 13 | 3 | 7 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 5.39 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 1 | 0 | 0 | 0 | 0.00 | .333 | 1.50 | - | - | - | 0.2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 8 | 0 | 2 | 1 | 7.08 | .372 | 1.78 | 11.6 | 4.5 | 5.3 | 34.1 | 44 | 27 | 27 | 7 | 17 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 |