| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 97 | 35 | 35 | 21 | 8 | 3.03 | .245 | 0.94 | 6.7 | 1.8 | 7.5 | 279.1 | 207 | 95 | 94 | 27 | 56 | 231 | 18 | 0 | 0 | 6 | 22 | 9 | 6 | 3.30 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 34 | 34 | 16 | 15 | 3.59 | .267 | 1.05 | 7.9 | 1.6 | 5.3 | 258.1 | 226 | 108 | 103 | 26 | 46 | 153 | 15 | 0 | 0 | 5 | 19 | 11 | 2 | 3.79 |
| SP | Snell, B.Snell, Blake † >> | 25 | 2018 | L | 81 | 33 | 33 | 16 | 8 | 3.21 | .265 | 1.05 | 6.4 | 3.1 | 7.6 | 215.2 | 153 | 80 | 77 | 23 | 74 | 182 | 1 | 0 | 0 | 0 | 26 | 6 | 3 | 3.81 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 50 | 31 | 31 | 12 | 5 | 3.40 | .297 | 1.25 | 6.8 | 4.4 | 6.9 | 209.1 | 158 | 82 | 79 | 15 | 103 | 160 | 3 | 0 | 0 | 3 | 20 | 4 | 3 | 3.94 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 74 | 0 | 3 | 3 | 4.19 | .337 | 1.51 | 8.5 | 5.1 | 9.1 | 77.1 | 73 | 38 | 36 | 10 | 44 | 78 | 0 | 8 | 4 | 0 | 0 | 1 | 0 | 4.42 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 28 | 0 | 3 | 3 | 3.70 | .305 | 1.23 | 8.6 | 2.6 | 7.1 | 24.1 | 23 | 11 | 10 | 1 | 7 | 19 | 0 | 4 | 2 | 0 | 0 | 2 | 0 | 3.08 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 28 | 0 | 1 | 0 | 3.68 | .302 | 1.30 | 7.1 | 4.7 | 9.9 | 29.1 | 23 | 12 | 12 | 3 | 15 | 32 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.69 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 54 | 19 | 0 | 2 | 3 | 3.74 | .256 | 1.02 | 7.1 | 2.1 | 5.1 | 65.0 | 51 | 29 | 27 | 9 | 15 | 37 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.40 |