| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 12 | 12 | 5 | 2 | 2.51 | .271 | 1.06 | 7.6 | 1.9 | 8.3 | 79.0 | 67 | 22 | 22 | 6 | 17 | 73 | 0 | 0 | 0 | 0 | 9 | 4 | 0 | 2.94 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 11 | 11 | 3 | 3 | 4.96 | .307 | 1.33 | 9.6 | 2.5 | 8.6 | 61.2 | 65 | 34 | 34 | 7 | 17 | 58 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 3.43 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 11 | 11 | 5 | 4 | 4.38 | .291 | 1.21 | 8.5 | 2.3 | 3.8 | 78.0 | 74 | 40 | 38 | 10 | 20 | 33 | 2 | 0 | 0 | 1 | 5 | 2 | 1 | 4.67 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 11 | 11 | 2 | 5 | 5.85 | .355 | 1.63 | 10.2 | 4.5 | 3.5 | 60.0 | 68 | 46 | 39 | 12 | 30 | 23 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 6.38 |
| CL | Kimbrel, C.Kimbrel, Craig $ >> | 24 | 2012 | R | 100 | 25 | 0 | 4 | 1 | 1.71 | .218 | 0.84 | 4.5 | 3.1 | 11.4 | 26.1 | 13 | 6 | 5 | 2 | 9 | 33 | 0 | 15 | 1 | 0 | 0 | 0 | 4 | 2.50 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 33 | 0 | 6 | 1 | 1.45 | .212 | 0.81 | 3.6 | 3.8 | 11.1 | 43.1 | 17 | 8 | 7 | 2 | 18 | 53 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.40 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 23 | 0 | 0 | 1 | 3.18 | .280 | 1.16 | 6.4 | 4.2 | 8.7 | 28.1 | 20 | 10 | 10 | 3 | 13 | 27 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 3.86 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 13 | 0 | 0 | 1 | 3.38 | .231 | 0.90 | 5.5 | 2.8 | 11.1 | 13.1 | 8 | 5 | 5 | 0 | 4 | 16 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1.46 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 7 | 0 | 1 | 0 | 4.66 | .326 | 1.45 | 12.0 | 2.0 | 7.0 | 9.2 | 12 | 5 | 5 | 0 | 2 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.11 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 7 | 0 | 0 | 1 | 2.16 | .242 | 0.84 | 3.4 | 4.5 | 9.0 | 8.1 | 3 | 2 | 2 | 1 | 4 | 8 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.50 |