| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 19 | 19 | 8 | 10 | 4.66 | .299 | 1.28 | 8.5 | 3.1 | 7.5 | 119.2 | 112 | 66 | 62 | 16 | 41 | 99 | 2 | 0 | 0 | 0 | 8 | 0 | 0 | 4.12 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 18 | 18 | 8 | 7 | 3.78 | .276 | 1.12 | 7.7 | 2.3 | 8.2 | 112.0 | 96 | 51 | 47 | 8 | 29 | 102 | 0 | 0 | 0 | 0 | 9 | 3 | 1 | 2.96 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 43 | 0 | 4 | 2 | 3.54 | .300 | 1.26 | 6.0 | 5.4 | 8.4 | 48.1 | 32 | 21 | 19 | 4 | 29 | 45 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 4.08 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 74 | 44 | 0 | 1 | 1 | 2.48 | .285 | 1.18 | 6.0 | 4.7 | 9.2 | 54.1 | 36 | 17 | 15 | 5 | 28 | 55 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.78 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 41 | 0 | 3 | 1 | 4.89 | .320 | 1.33 | 5.7 | 6.3 | 9.6 | 46.0 | 29 | 27 | 25 | 7 | 32 | 49 | 0 | 2 | 0 | 0 | 0 | 4 | 1 | 5.20 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 57 | 32 | 0 | 2 | 1 | 5.75 | .325 | 1.44 | 8.5 | 4.5 | 8.0 | 36.0 | 34 | 25 | 23 | 7 | 18 | 32 | 0 | 3 | 3 | 0 | 0 | 0 | 3 | 5.25 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 1 | 0 | 0 | 0 | 54.00 | .750 | 6.00 | - | - | - | 0.1 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | - |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 8 | 0 | 0 | 1 | 1.29 | .300 | 1.29 | 7.7 | 3.9 | 5.1 | 7.0 | 6 | 1 | 1 | 0 | 3 | 4 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.14 |