| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 19 | 19 | 7 | 6 | 4.16 | .294 | 1.23 | 8.3 | 2.8 | 8.8 | 114.2 | 105 | 54 | 53 | 13 | 36 | 111 | 1 | 0 | 0 | 1 | 11 | 2 | 0 | 3.54 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 18 | 17 | 8 | 6 | 4.39 | .316 | 1.35 | 8.7 | 3.5 | 8.2 | 106.2 | 103 | 54 | 52 | 13 | 41 | 96 | 0 | 0 | 0 | 0 | 8 | 4 | 3 | 4.06 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 18 | 16 | 4 | 8 | 7.13 | .369 | 1.74 | 10.1 | 5.6 | 7.7 | 83.1 | 93 | 68 | 66 | 12 | 52 | 71 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 5.08 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 56 | 0 | 3 | 4 | 5.23 | .329 | 1.45 | 9.4 | 3.6 | 10.3 | 62.0 | 65 | 37 | 36 | 12 | 25 | 71 | 0 | 18 | 5 | 0 | 0 | 1 | 1 | 4.48 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 59 | 0 | 2 | 1 | 4.09 | .299 | 1.25 | 8.0 | 3.3 | 8.6 | 70.1 | 62 | 33 | 32 | 11 | 26 | 67 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 4.33 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 50 | 0 | 4 | 0 | 3.48 | .306 | 1.31 | 6.2 | 5.7 | 9.2 | 54.1 | 37 | 23 | 21 | 6 | 34 | 55 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.35 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 38 | 0 | 4 | 2 | 6.08 | .360 | 1.69 | 9.2 | 6.1 | 8.5 | 50.1 | 51 | 36 | 34 | 8 | 34 | 47 | 0 | 0 | 1 | 0 | 0 | 0 | 5 | 5.24 |