| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 13 | 13 | 6 | 3 | 3.53 | .284 | 1.18 | 8.7 | 1.9 | 10.8 | 79.0 | 76 | 33 | 31 | 8 | 17 | 95 | 0 | 0 | 0 | 0 | 8 | 1 | 0 | 2.59 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 14 | 13 | 3 | 8 | 8.16 | .394 | 1.88 | 12.6 | 4.4 | 6.8 | 57.1 | 80 | 55 | 52 | 11 | 28 | 43 | 1 | 0 | 0 | 0 | 4 | 4 | 1 | 5.68 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 14 | 13 | 5 | 4 | 5.84 | .333 | 1.49 | 10.8 | 2.6 | 4.9 | 74.0 | 89 | 55 | 48 | 12 | 21 | 40 | 2 | 0 | 0 | 0 | 4 | 1 | 0 | 4.92 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 71 | 13 | 12 | 4 | 4 | 5.09 | .309 | 1.33 | 9.6 | 2.4 | 5.0 | 81.1 | 86 | 49 | 46 | 14 | 22 | 45 | 2 | 0 | 0 | 0 | 5 | 1 | 3 | 4.99 |
| CL | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 36 | 0 | 1 | 0 | 1.15 | .259 | 1.05 | 5.8 | 3.7 | 7.8 | 39.0 | 25 | 5 | 5 | 1 | 16 | 34 | 0 | 16 | 2 | 0 | 0 | 0 | 0 | 2.82 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 40 | 0 | 2 | 1 | 2.20 | .258 | 0.98 | 5.6 | 3.2 | 9.0 | 45.0 | 28 | 13 | 11 | 2 | 16 | 45 | 0 | 0 | 2 | 0 | 0 | 3 | 0 | 2.84 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 32 | 0 | 3 | 2 | 4.64 | .313 | 1.36 | 8.2 | 4.1 | 6.3 | 33.0 | 30 | 18 | 17 | 2 | 15 | 23 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.76 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 27 | 0 | 2 | 1 | 3.07 | .320 | 1.39 | 9.4 | 3.1 | 8.8 | 41.0 | 43 | 14 | 14 | 3 | 14 | 40 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 3.10 |