| SP | Johnson, W.Johnson, Walter $ >> | 26 | 1913 | R | 95 | 34 | 34 | 14 | 12 | 4.17 | .287 | 1.19 | 8.7 | 2.1 | 5.5 | 233.0 | 224 | 111 | 108 | 27 | 54 | 142 | 4 | 0 | 0 | 1 | 19 | 3 | 2 | 4.02 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 32 | 32 | 10 | 13 | 4.56 | .307 | 1.32 | 8.9 | 3.0 | 8.1 | 207.1 | 205 | 109 | 105 | 27 | 68 | 186 | 3 | 0 | 0 | 0 | 17 | 3 | 3 | 3.93 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 32 | 32 | 5 | 15 | 4.69 | .310 | 1.33 | 8.8 | 3.1 | 5.3 | 169.0 | 166 | 89 | 88 | 21 | 58 | 99 | 0 | 0 | 0 | 0 | 9 | 4 | 6 | 4.54 |
| SP | McLain, D.McLain, Denny † >> | 24 | 1968 | R | 79 | 31 | 31 | 14 | 11 | 3.49 | .300 | 1.27 | 8.8 | 2.6 | 4.8 | 222.0 | 216 | 94 | 86 | 20 | 65 | 118 | 13 | 0 | 0 | 3 | 21 | 5 | 1 | 4.05 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 65 | 0 | 2 | 3 | 2.56 | .272 | 1.09 | 7.3 | 2.6 | 10.4 | 70.1 | 57 | 21 | 20 | 7 | 20 | 81 | 0 | 5 | 8 | 0 | 0 | 2 | 0 | 2.93 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 79 | 0 | 9 | 5 | 3.87 | .302 | 1.30 | 6.5 | 5.3 | 9.2 | 97.2 | 70 | 44 | 42 | 12 | 57 | 99 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 4.33 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 60 | 0 | 3 | 1 | 3.64 | .307 | 1.30 | 8.1 | 3.7 | 8.5 | 59.1 | 53 | 24 | 24 | 7 | 24 | 56 | 0 | 3 | 2 | 0 | 0 | 2 | 4 | 3.97 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 48 | 0 | 3 | 3 | 2.60 | .278 | 1.14 | 6.4 | 3.9 | 5.6 | 55.1 | 39 | 19 | 16 | 4 | 24 | 34 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 4.07 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 27 | 2 | 4 | 2 | 4.33 | .305 | 1.30 | 8.9 | 2.8 | 5.1 | 112.1 | 111 | 54 | 54 | 17 | 35 | 63 | 1 | 2 | 0 | 0 | 1 | 2 | 1 | 4.84 |