| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 34 | 34 | 20 | 10 | 3.93 | .307 | 1.30 | 8.4 | 3.3 | 8.9 | 245.0 | 229 | 113 | 107 | 24 | 90 | 243 | 7 | 0 | 0 | 2 | 21 | 7 | 5 | 3.48 |
| SP | Maddux, G.Maddux, Greg $ >> | 29 | 1995 | R | 89 | 35 | 35 | 11 | 17 | 4.35 | .288 | 1.19 | 8.7 | 2.1 | 6.1 | 265.0 | 255 | 132 | 128 | 32 | 61 | 181 | 10 | 0 | 0 | 2 | 17 | 6 | 1 | 3.96 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 33 | 33 | 23 | 7 | 3.05 | .259 | 1.04 | 7.5 | 1.8 | 4.6 | 257.0 | 215 | 89 | 87 | 25 | 51 | 131 | 8 | 0 | 0 | 2 | 23 | 3 | 2 | 3.88 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 81 | 33 | 33 | 11 | 14 | 4.41 | .305 | 1.29 | 8.3 | 3.3 | 7.8 | 196.0 | 181 | 100 | 96 | 24 | 72 | 169 | 0 | 0 | 0 | 0 | 17 | 5 | 6 | 4.05 |
| SP | Scott, M.Scott, Mike # >> | 31 | 1986 | R | 87 | 31 | 31 | 11 | 14 | 5.17 | .312 | 1.33 | 8.9 | 3.0 | 8.0 | 198.1 | 196 | 115 | 114 | 29 | 67 | 176 | 6 | 0 | 0 | 1 | 16 | 7 | 1 | 4.25 |
| RP | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 91 | 0 | 9 | 4 | 4.13 | .284 | 1.19 | 8.4 | 2.4 | 9.7 | 106.2 | 99 | 49 | 49 | 17 | 28 | 114 | 0 | 16 | 4 | 0 | 0 | 0 | 1 | 3.73 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 92 | 59 | 0 | 3 | 1 | 2.85 | .266 | 1.07 | 6.6 | 3.1 | 10.1 | 72.2 | 53 | 24 | 23 | 6 | 25 | 81 | 0 | 9 | 0 | 0 | 0 | 1 | 2 | 2.92 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 36 | 0 | 3 | 0 | 3.35 | .275 | 1.14 | 7.3 | 2.9 | 8.6 | 43.0 | 35 | 16 | 16 | 5 | 14 | 41 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.58 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 26 | 0 | 1 | 2 | 4.31 | .288 | 1.21 | 9.0 | 2.0 | 9.3 | 31.1 | 31 | 16 | 15 | 6 | 7 | 32 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.13 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 24 | 0 | 2 | 2 | 4.18 | .311 | 1.35 | 9.0 | 3.5 | 6.3 | 23.2 | 23 | 11 | 11 | 5 | 9 | 16 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 5.61 |
| SP | Rudolph, D.Rudolph, Dick >> | 27 | 1914 | R | 15 | 7 | 2 | 1 | 1 | 2.82 | .323 | 1.43 | 8.2 | 4.9 | 2.9 | 22.1 | 20 | 7 | 7 | 3 | 12 | 7 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 5.77 |