| SP | deGrom, J.deGrom, Jacob $$ >> | 33 | 2021 | R | 100 | 26 | 26 | 8 | 10 | 2.98 | .260 | 1.04 | 6.8 | 2.5 | 8.8 | 181.0 | 137 | 60 | 60 | 21 | 51 | 177 | 1 | 0 | 0 | 0 | 19 | 3 | 0 | 3.45 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 25 | 25 | 10 | 12 | 4.73 | .311 | 1.34 | 9.4 | 2.8 | 8.2 | 163.2 | 170 | 92 | 86 | 27 | 50 | 148 | 6 | 0 | 0 | 0 | 14 | 2 | 5 | 4.29 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 25 | 25 | 17 | 5 | 2.69 | .241 | 0.93 | 7.3 | 1.1 | 5.2 | 197.2 | 160 | 61 | 59 | 17 | 24 | 113 | 15 | 0 | 0 | 4 | 19 | 4 | 2 | 3.40 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 25 | 25 | 9 | 8 | 6.21 | .337 | 1.50 | 9.9 | 3.6 | 7.1 | 130.1 | 143 | 92 | 90 | 23 | 52 | 103 | 0 | 0 | 0 | 0 | 10 | 4 | 6 | 5.01 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 79 | 24 | 24 | 13 | 10 | 3.90 | .294 | 1.23 | 8.8 | 2.3 | 5.1 | 161.2 | 158 | 77 | 70 | 20 | 41 | 92 | 1 | 0 | 0 | 1 | 14 | 3 | 1 | 4.29 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 61 | 0 | 4 | 4 | 3.36 | .277 | 1.13 | 8.0 | 2.3 | 8.6 | 72.1 | 64 | 28 | 27 | 11 | 18 | 69 | 0 | 5 | 2 | 0 | 0 | 1 | 1 | 3.86 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 91 | 50 | 0 | 4 | 2 | 3.45 | .265 | 1.06 | 8.2 | 1.4 | 8.1 | 57.1 | 52 | 22 | 22 | 5 | 9 | 51 | 0 | 11 | 2 | 0 | 0 | 1 | 0 | 2.88 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 28 | 0 | 1 | 0 | 2.08 | .260 | 0.99 | 6.3 | 2.7 | 8.7 | 30.1 | 21 | 7 | 7 | 4 | 9 | 29 | 0 | 8 | 0 | 0 | 0 | 2 | 0 | 3.90 |
| RP | Sambito, J.Sambito, Joe >> | 28 | 1980 | L | 32 | 16 | 0 | 0 | 1 | 1.80 | .211 | 0.80 | 6.3 | 0.9 | 3.6 | 20.0 | 14 | 4 | 4 | 2 | 2 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.80 |
| RP | Wilson, B.Wilson, Brian >> | 28 | 2010 | R | 6 | 15 | 0 | 0 | 0 | 3.86 | .329 | 1.47 | 7.3 | 6.2 | 10.1 | 16.1 | 13 | 7 | 7 | 3 | 11 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.25 |