| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 26 | 26 | 10 | 11 | 2.34 | .272 | 1.10 | 7.3 | 2.7 | 8.0 | 165.1 | 133 | 47 | 43 | 13 | 49 | 147 | 1 | 0 | 0 | 1 | 19 | 3 | 2 | 3.19 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 26 | 25 | 12 | 6 | 2.96 | .284 | 1.17 | 7.5 | 3.1 | 4.7 | 170.1 | 141 | 60 | 56 | 8 | 58 | 89 | 2 | 1 | 0 | 1 | 17 | 4 | 3 | 3.66 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 85 | 25 | 25 | 12 | 5 | 3.28 | .277 | 1.14 | 8.4 | 1.9 | 4.4 | 159.0 | 149 | 60 | 58 | 14 | 33 | 78 | 2 | 0 | 0 | 2 | 18 | 1 | 3 | 3.81 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 84 | 24 | 24 | 15 | 5 | 3.14 | .262 | 1.02 | 7.0 | 2.2 | 3.8 | 203.2 | 159 | 71 | 71 | 22 | 49 | 86 | 14 | 0 | 0 | 2 | 14 | 9 | 3 | 4.42 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 24 | 23 | 13 | 9 | 3.99 | .312 | 1.32 | 8.3 | 3.6 | 7.0 | 167.0 | 154 | 75 | 74 | 20 | 67 | 129 | 3 | 0 | 0 | 1 | 12 | 6 | 3 | 4.32 |
| RP | Gagne, E.Gagne, Eric $ >> | 27 | 2003 | R | 98 | 65 | 0 | 1 | 5 | 2.45 | .279 | 1.11 | 6.0 | 4.1 | 10.5 | 84.1 | 56 | 30 | 23 | 4 | 38 | 98 | 0 | 10 | 3 | 0 | 0 | 4 | 1 | 2.79 |
| RP | Kuo, H.Kuo, Hong-Chih † >> | 29 | 2010 | L | 90 | 50 | 0 | 6 | 3 | 3.19 | .332 | 1.45 | 8.7 | 4.6 | 8.0 | 53.2 | 51 | 27 | 19 | 5 | 27 | 47 | 0 | 9 | 5 | 0 | 0 | 2 | 2 | 4.09 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 27 | 0 | 1 | 0 | 1.50 | .231 | 0.90 | 4.8 | 3.3 | 3.3 | 30.0 | 16 | 5 | 5 | 3 | 11 | 11 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 4.67 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 16 | 0 | 2 | 1 | 0.50 | .217 | 0.83 | 3.0 | 4.5 | 4.5 | 18.0 | 6 | 1 | 1 | 0 | 9 | 9 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Radatz, D.Radatz, Dick >> | 27 | 1964 | R | 36 | 4 | 0 | 0 | 0 | 1.80 | .250 | 1.00 | 4.5 | 4.5 | 6.3 | 10.0 | 5 | 2 | 2 | 0 | 5 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.10 |