| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 97 | 18 | 18 | 5 | 10 | 3.89 | .270 | 1.09 | 7.6 | 2.2 | 8.6 | 145.2 | 123 | 63 | 63 | 19 | 36 | 138 | 8 | 0 | 0 | 0 | 8 | 3 | 3 | 3.61 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 17 | 17 | 3 | 11 | 4.62 | .328 | 1.46 | 10.7 | 2.5 | 5.5 | 122.2 | 145 | 72 | 63 | 22 | 34 | 74 | 2 | 0 | 0 | 0 | 7 | 1 | 1 | 4.99 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 17 | 17 | 4 | 10 | 5.44 | .350 | 1.57 | 9.6 | 4.5 | 3.9 | 97.2 | 104 | 62 | 59 | 14 | 49 | 42 | 0 | 0 | 0 | 0 | 5 | 5 | 3 | 5.68 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 55 | 17 | 17 | 3 | 7 | 5.62 | .349 | 1.56 | 10.6 | 3.5 | 5.1 | 99.1 | 117 | 68 | 62 | 13 | 38 | 56 | 1 | 0 | 0 | 0 | 6 | 5 | 6 | 4.88 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 43 | 0 | 3 | 3 | 4.30 | .323 | 1.39 | 6.4 | 6.2 | 9.3 | 52.1 | 37 | 26 | 25 | 1 | 36 | 54 | 0 | 2 | 2 | 0 | 0 | 2 | 5 | 3.37 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 47 | 0 | 4 | 2 | 2.66 | .324 | 1.42 | 7.2 | 5.8 | 8.3 | 50.2 | 40 | 18 | 15 | 5 | 32 | 46 | 0 | 6 | 3 | 0 | 0 | 1 | 0 | 4.44 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 34 | 0 | 2 | 2 | 5.15 | .364 | 1.69 | 9.3 | 6.3 | 9.3 | 36.2 | 37 | 27 | 21 | 6 | 25 | 37 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 5.28 |
| RP | Abernathy, T.Abernathy, Ted >> | 34 | 1967 | R | 49 | 15 | 0 | 1 | 1 | 2.91 | .278 | 1.11 | 4.3 | 6.0 | 5.6 | 21.2 | 10 | 9 | 7 | 1 | 14 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.52 |
| SP | Cooper, M.Cooper, Mort >> | 29 | 1942 | R | 47 | 5 | 0 | 0 | 0 | 1.80 | .375 | 1.80 | 10.8 | 5.4 | 9.0 | 5.0 | 6 | 1 | 1 | 0 | 3 | 5 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.80 |