| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 29 | 29 | 10 | 12 | 3.63 | .313 | 1.32 | 8.3 | 3.6 | 8.4 | 178.1 | 164 | 80 | 72 | 20 | 71 | 166 | 0 | 0 | 0 | 0 | 17 | 9 | 3 | 3.94 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 28 | 28 | 7 | 16 | 4.28 | .304 | 1.29 | 8.8 | 2.8 | 5.3 | 181.0 | 176 | 93 | 86 | 19 | 57 | 107 | 8 | 0 | 0 | 2 | 16 | 4 | 6 | 4.19 |
| SP | Harden, R.Harden, Rich # >> | 27 | 2008 | R | 61 | 27 | 27 | 8 | 11 | 4.58 | .311 | 1.33 | 8.2 | 3.8 | 8.5 | 153.1 | 139 | 79 | 78 | 21 | 65 | 144 | 0 | 0 | 0 | 0 | 12 | 4 | 1 | 4.25 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 28 | 27 | 5 | 6 | 3.70 | .294 | 1.22 | 8.2 | 2.8 | 8.6 | 116.2 | 106 | 48 | 48 | 14 | 36 | 111 | 0 | 0 | 0 | 0 | 0 | 4 | 4 | 3.69 |
| RP | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 95 | 77 | 0 | 8 | 0 | 2.63 | .245 | 0.97 | 6.0 | 2.8 | 8.8 | 113.0 | 75 | 36 | 33 | 12 | 35 | 111 | 0 | 6 | 3 | 0 | 0 | 0 | 0 | 3.35 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 70 | 0 | 7 | 2 | 4.83 | .317 | 1.37 | 8.4 | 3.9 | 7.4 | 78.1 | 73 | 43 | 42 | 9 | 34 | 64 | 0 | 5 | 0 | 0 | 0 | 2 | 3 | 4.24 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 64 | 0 | 1 | 2 | 2.88 | .280 | 1.13 | 4.6 | 5.5 | 6.9 | 78.0 | 40 | 26 | 25 | 5 | 48 | 60 | 0 | 4 | 2 | 0 | 0 | 3 | 3 | 4.26 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 50 | 55 | 0 | 2 | 1 | 2.90 | .260 | 1.05 | 7.4 | 2.2 | 4.3 | 71.1 | 58 | 24 | 23 | 8 | 17 | 34 | 0 | 9 | 1 | 0 | 0 | 0 | 0 | 4.23 |
| RP | Frohwirth, T.Frohwirth, Todd >> | 29 | 1991 | R | 42 | 43 | 0 | 4 | 7 | 3.35 | .300 | 1.29 | 7.6 | 4.1 | 4.4 | 53.2 | 45 | 21 | 20 | 1 | 24 | 26 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.62 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 34 | 1 | 4 | 5 | 4.94 | .332 | 1.48 | 7.5 | 5.8 | 7.6 | 71.0 | 59 | 40 | 39 | 7 | 46 | 60 | 0 | 4 | 0 | 0 | 0 | 1 | 2 | 4.58 |