| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 23 | 23 | 8 | 8 | 4.17 | .307 | 1.30 | 8.9 | 2.8 | 5.4 | 146.2 | 145 | 68 | 68 | 16 | 46 | 88 | 2 | 0 | 0 | 0 | 12 | 4 | 5 | 4.25 |
| SP | Ryan, N.Ryan, Nolan $$ >> | 44 | 1991 | R | 74 | 23 | 23 | 11 | 8 | 3.49 | .303 | 1.27 | 6.8 | 4.7 | 8.1 | 144.1 | 108 | 61 | 56 | 15 | 75 | 129 | 1 | 0 | 0 | 0 | 14 | 5 | 6 | 4.23 |
| SP | Fernandez, S.Fernandez, Sid # >> | 23 | 1985 | L | 50 | 23 | 23 | 10 | 7 | 3.65 | .278 | 1.15 | 7.1 | 3.3 | 7.7 | 150.1 | 118 | 63 | 61 | 13 | 55 | 128 | 2 | 0 | 0 | 1 | 15 | 1 | 2 | 3.54 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 62 | 22 | 22 | 9 | 7 | 2.72 | .280 | 1.16 | 5.8 | 4.6 | 3.4 | 152.1 | 98 | 49 | 46 | 7 | 78 | 57 | 5 | 0 | 0 | 3 | 16 | 2 | 1 | 4.43 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 38 | 0 | 3 | 1 | 1.29 | .227 | 0.88 | 4.7 | 3.2 | 7.3 | 42.0 | 22 | 6 | 6 | 3 | 15 | 34 | 0 | 22 | 0 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 55 | 0 | 4 | 4 | 4.37 | .302 | 1.27 | 7.6 | 3.9 | 9.0 | 70.0 | 59 | 38 | 34 | 11 | 30 | 70 | 0 | 4 | 3 | 0 | 0 | 2 | 0 | 4.41 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 46 | 0 | 2 | 3 | 5.01 | .330 | 1.37 | 8.6 | 3.9 | 7.6 | 46.2 | 44 | 27 | 26 | 10 | 20 | 39 | 0 | 1 | 2 | 0 | 0 | 5 | 1 | 5.76 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 27 | 0 | 1 | 1 | 2.67 | .277 | 1.11 | 6.0 | 4.0 | 6.0 | 27.0 | 18 | 8 | 8 | 3 | 12 | 18 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.56 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 77 | 17 | 0 | 1 | 2 | 4.08 | .284 | 1.19 | 9.5 | 1.6 | 12.2 | 17.2 | 18 | 8 | 8 | 3 | 3 | 23 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.12 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 13 | 0 | 0 | 0 | 3.00 | .194 | 0.72 | 4.0 | 2.5 | 9.5 | 18.0 | 8 | 6 | 6 | 3 | 5 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.89 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 2 | 0 | 0 | 1 | 13.50 | .500 | 3.00 | 18.0 | 18.0 | 9.0 | 1.1 | 2 | 2 | 2 | 1 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 20.00 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 19 | 1 | 4 | 3 | 3.19 | .276 | 1.11 | 7.4 | 2.6 | 7.7 | 62.0 | 51 | 23 | 22 | 2 | 18 | 53 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 2.68 |