| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 24 | 24 | 8 | 11 | 3.58 | .293 | 1.21 | 7.9 | 3.0 | 7.9 | 178.2 | 157 | 75 | 71 | 17 | 59 | 156 | 4 | 0 | 0 | 0 | 14 | 6 | 2 | 3.58 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 23 | 23 | 8 | 10 | 3.87 | .290 | 1.20 | 7.5 | 3.3 | 7.4 | 153.2 | 128 | 70 | 66 | 9 | 56 | 125 | 2 | 0 | 0 | 0 | 15 | 4 | 2 | 3.31 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 23 | 23 | 6 | 6 | 4.64 | .321 | 1.39 | 9.5 | 3.1 | 4.7 | 120.1 | 126 | 70 | 62 | 15 | 41 | 63 | 0 | 0 | 0 | 0 | 3 | 4 | 6 | 4.70 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 23 | 23 | 9 | 9 | 4.65 | .295 | 1.24 | 9.0 | 2.2 | 5.5 | 153.0 | 153 | 82 | 79 | 27 | 37 | 93 | 1 | 0 | 0 | 0 | 12 | 2 | 3 | 4.84 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 69 | 22 | 22 | 7 | 9 | 5.16 | .332 | 1.47 | 10.0 | 3.3 | 5.8 | 137.2 | 152 | 91 | 79 | 20 | 50 | 89 | 2 | 0 | 0 | 1 | 7 | 3 | 1 | 4.76 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 42 | 0 | 3 | 5 | 3.65 | .257 | 1.04 | 6.8 | 2.7 | 7.4 | 44.1 | 33 | 18 | 18 | 9 | 13 | 36 | 0 | 26 | 3 | 0 | 0 | 0 | 1 | 4.91 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 54 | 0 | 5 | 1 | 3.34 | .250 | 1.00 | 7.3 | 1.7 | 8.0 | 62.0 | 50 | 23 | 23 | 6 | 12 | 55 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 3.06 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 21 | 0 | 3 | 2 | 3.28 | .333 | 1.46 | 9.8 | 3.8 | 7.5 | 24.2 | 26 | 11 | 9 | 4 | 10 | 20 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.88 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 17 | 0 | 1 | 0 | 3.92 | .279 | 1.11 | 5.9 | 4.5 | 6.3 | 20.2 | 13 | 9 | 9 | 0 | 10 | 14 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.25 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 17 | 1 | 6 | 1 | 2.91 | .294 | 1.25 | 8.4 | 2.9 | 8.1 | 74.1 | 69 | 28 | 24 | 7 | 24 | 67 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.39 |