| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 21 | 21 | 8 | 7 | 4.09 | .298 | 1.26 | 9.5 | 1.8 | 3.8 | 156.1 | 165 | 78 | 71 | 13 | 32 | 65 | 6 | 0 | 0 | 3 | 11 | 2 | 5 | 3.90 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 20 | 20 | 9 | 4 | 3.77 | .291 | 1.21 | 8.5 | 2.5 | 6.4 | 138.1 | 130 | 59 | 58 | 10 | 38 | 98 | 5 | 0 | 0 | 2 | 13 | 2 | 4 | 3.39 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 20 | 20 | 7 | 8 | 6.00 | .368 | 1.69 | 9.9 | 5.3 | 8.1 | 102.0 | 112 | 71 | 68 | 21 | 60 | 92 | 0 | 0 | 0 | 0 | 6 | 6 | 1 | 5.81 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 19 | 19 | 1 | 9 | 8.00 | .401 | 1.98 | 14.0 | 4.0 | 7.5 | 68.2 | 106 | 71 | 61 | 18 | 30 | 57 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 6.18 |
| RP | Jansen, K.Jansen, Kenley # >> | 28 | 2016 | R | 97 | 63 | 0 | 0 | 4 | 4.95 | .307 | 1.31 | 9.3 | 2.5 | 9.2 | 87.1 | 90 | 50 | 48 | 14 | 24 | 89 | 0 | 4 | 6 | 0 | 0 | 2 | 1 | 3.94 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 64 | 0 | 5 | 4 | 4.03 | .291 | 1.22 | 8.8 | 2.2 | 6.4 | 87.0 | 85 | 45 | 39 | 11 | 21 | 62 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 3.98 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 53 | 0 | 1 | 2 | 5.46 | .364 | 1.71 | 9.2 | 6.3 | 6.1 | 56.0 | 57 | 35 | 34 | 10 | 39 | 38 | 0 | 4 | 1 | 0 | 0 | 0 | 3 | 6.05 |
| RP | Fingers, R.Fingers, Rollie >> | 35 | 1981 | R | 53 | 42 | 0 | 5 | 5 | 3.29 | .278 | 1.14 | 8.2 | 2.2 | 5.3 | 65.2 | 59 | 24 | 24 | 8 | 16 | 38 | 0 | 6 | 3 | 0 | 0 | 1 | 0 | 4.22 |