| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 21 | 21 | 9 | 6 | 2.58 | .267 | 1.07 | 7.2 | 2.5 | 9.2 | 150.0 | 120 | 43 | 43 | 13 | 41 | 153 | 0 | 0 | 0 | 0 | 16 | 3 | 0 | 2.97 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 20 | 20 | 7 | 8 | 4.31 | .324 | 1.43 | 9.8 | 3.0 | 7.6 | 121.0 | 132 | 72 | 58 | 14 | 41 | 102 | 0 | 0 | 0 | 0 | 10 | 1 | 3 | 3.86 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 61 | 20 | 20 | 9 | 4 | 3.51 | .296 | 1.24 | 6.6 | 4.7 | 4.6 | 112.2 | 82 | 48 | 44 | 8 | 58 | 57 | 1 | 0 | 0 | 1 | 10 | 2 | 0 | 4.52 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 67 | 21 | 20 | 7 | 7 | 4.16 | .309 | 1.31 | 8.8 | 3.0 | 5.8 | 125.1 | 122 | 69 | 58 | 14 | 42 | 81 | 3 | 0 | 0 | 0 | 11 | 4 | 3 | 4.26 |
| RP | Benoit, J.Benoit, Joaquin # >> | 33 | 2010 | R | 95 | 38 | 0 | 7 | 2 | 4.47 | .302 | 1.29 | 8.4 | 3.3 | 9.6 | 46.1 | 43 | 23 | 23 | 12 | 17 | 49 | 0 | 0 | 3 | 0 | 0 | 0 | 2 | 5.37 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 31 | 0 | 2 | 1 | 4.62 | .323 | 1.41 | 9.5 | 3.2 | 4.1 | 37.0 | 39 | 19 | 19 | 5 | 13 | 17 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.97 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 28 | 0 | 1 | 1 | 2.56 | .312 | 1.36 | 7.5 | 4.9 | 9.3 | 31.2 | 26 | 9 | 9 | 1 | 17 | 32 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 3.00 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 18 | 0 | 0 | 1 | 3.44 | .247 | 0.93 | 6.0 | 2.5 | 7.5 | 18.1 | 12 | 7 | 7 | 3 | 5 | 15 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.50 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 43 | 0 | 5 | 3 | 1.98 | .254 | 1.02 | 4.9 | 4.3 | 8.3 | 50.0 | 27 | 12 | 11 | 0 | 24 | 46 | 0 | 23 | 4 | 0 | 0 | 0 | 4 | 2.60 |