| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 24 | 24 | 16 | 4 | 2.89 | .254 | 1.00 | 6.7 | 2.3 | 8.7 | 158.2 | 118 | 58 | 51 | 19 | 40 | 153 | 1 | 0 | 0 | 0 | 20 | 4 | 0 | 3.46 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 24 | 24 | 10 | 7 | 5.02 | .328 | 1.43 | 9.6 | 3.2 | 9.3 | 131.0 | 140 | 75 | 73 | 24 | 47 | 135 | 0 | 0 | 0 | 0 | 11 | 5 | 3 | 4.51 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 69 | 0 | 3 | 4 | 4.09 | .247 | 0.97 | 6.6 | 2.2 | 10.1 | 81.1 | 59 | 37 | 37 | 8 | 20 | 91 | 0 | 31 | 4 | 0 | 0 | 1 | 1 | 2.81 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 94 | 70 | 0 | 0 | 5 | 3.91 | .315 | 1.38 | 8.3 | 4.2 | 10.0 | 78.1 | 72 | 38 | 34 | 11 | 36 | 87 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 3.99 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 49 | 0 | 7 | 3 | 3.61 | .335 | 1.47 | 8.3 | 5.0 | 8.3 | 52.1 | 48 | 26 | 21 | 7 | 29 | 48 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 4.69 |