| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 15 | 15 | 5 | 3 | 3.61 | .265 | 1.06 | 7.5 | 2.1 | 11.2 | 92.1 | 77 | 41 | 37 | 14 | 21 | 114 | 0 | 0 | 0 | 0 | 10 | 2 | 0 | 3.25 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 15 | 15 | 2 | 7 | 8.35 | .359 | 1.65 | 11.7 | 3.1 | 9.1 | 69.0 | 90 | 66 | 64 | 21 | 24 | 70 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 6.06 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 14 | 14 | 5 | 5 | 4.32 | .321 | 1.41 | 9.5 | 3.3 | 5.4 | 93.2 | 98 | 46 | 45 | 8 | 34 | 56 | 3 | 0 | 0 | 1 | 7 | 1 | 2 | 4.04 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 16 | 14 | 3 | 8 | 6.81 | .329 | 1.46 | 10.2 | 3.0 | 5.4 | 75.1 | 85 | 60 | 57 | 16 | 25 | 45 | 0 | 0 | 0 | 0 | 4 | 1 | 3 | 5.61 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 68 | 16 | 14 | 4 | 9 | 8.65 | .395 | 1.94 | 13.3 | 4.3 | 8.7 | 59.1 | 87 | 60 | 57 | 16 | 28 | 57 | 0 | 0 | 0 | 0 | 4 | 1 | 3 | 6.07 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 42 | 0 | 2 | 4 | 3.71 | .269 | 1.07 | 7.0 | 2.7 | 7.6 | 53.1 | 41 | 23 | 22 | 7 | 16 | 45 | 0 | 10 | 6 | 0 | 0 | 2 | 1 | 4.04 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 43 | 0 | 2 | 2 | 5.47 | .332 | 1.45 | 9.2 | 3.9 | 9.5 | 51.0 | 52 | 31 | 31 | 12 | 22 | 54 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 5.35 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 45 | 0 | 3 | 1 | 3.63 | .268 | 1.10 | 7.6 | 2.3 | 10.4 | 52.0 | 44 | 21 | 21 | 7 | 13 | 60 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.19 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 46 | 0 | 1 | 1 | 5.40 | .347 | 1.57 | 8.8 | 5.4 | 8.6 | 43.1 | 42 | 26 | 26 | 4 | 26 | 41 | 0 | 0 | 2 | 0 | 0 | 1 | 8 | 4.19 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 39 | 0 | 5 | 0 | 6.10 | .333 | 1.50 | 11.8 | 1.9 | 7.1 | 48.2 | 63 | 34 | 33 | 12 | 10 | 38 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.29 |