| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 28 | 28 | 13 | 10 | 3.24 | .263 | 1.05 | 7.3 | 2.1 | 5.9 | 224.2 | 182 | 85 | 81 | 30 | 53 | 146 | 10 | 0 | 0 | 2 | 17 | 5 | 2 | 4.21 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 28 | 28 | 10 | 15 | 5.85 | .331 | 1.46 | 10.5 | 2.6 | 6.0 | 192.1 | 225 | 137 | 125 | 38 | 56 | 127 | 9 | 0 | 0 | 0 | 9 | 4 | 1 | 5.19 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 27 | 24 | 10 | 8 | 5.43 | .325 | 1.40 | 9.5 | 3.1 | 5.5 | 167.1 | 177 | 103 | 101 | 24 | 58 | 102 | 3 | 0 | 0 | 1 | 11 | 7 | 5 | 4.81 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 67 | 0 | 2 | 1 | 2.23 | .284 | 1.14 | 6.5 | 3.8 | 12.6 | 40.1 | 29 | 12 | 10 | 3 | 17 | 56 | 0 | 2 | 0 | 0 | 0 | 2 | 3 | 2.60 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 66 | 0 | 5 | 1 | 2.82 | .292 | 1.22 | 7.6 | 3.4 | 7.6 | 51.0 | 43 | 21 | 16 | 5 | 19 | 43 | 0 | 5 | 4 | 0 | 0 | 1 | 0 | 3.76 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 41 | 0 | 0 | 2 | 2.32 | .262 | 1.06 | 7.0 | 2.6 | 9.3 | 31.0 | 24 | 9 | 8 | 2 | 9 | 32 | 0 | 7 | 1 | 0 | 0 | 0 | 0 | 2.65 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 11 | 0 | 1 | 2 | 5.79 | .378 | 1.82 | 14.0 | 3.0 | 7.0 | 9.1 | 14 | 9 | 6 | 2 | 3 | 7 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 5.33 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 20 | 0 | 2 | 0 | 3.22 | .239 | 0.94 | 6.1 | 2.5 | 8.6 | 22.1 | 15 | 8 | 8 | 2 | 6 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.09 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 15 | 3 | 0 | 3 | 5.57 | .340 | 1.53 | 10.4 | 3.5 | 6.9 | 64.2 | 74 | 43 | 40 | 7 | 25 | 49 | 1 | 1 | 0 | 0 | 0 | 1 | 3 | 4.11 |