| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 96 | 7 | 7 | 1 | 5 | 6.58 | .304 | 1.31 | 10.4 | 1.6 | 5.5 | 39.2 | 45 | 30 | 29 | 11 | 7 | 24 | 2 | 0 | 0 | 0 | 2 | 0 | 1 | 5.97 |
| SP | Skenes, P.Skenes, Paul >> | 22 | 2024 | R | 93 | 4 | 4 | 2 | 1 | 4.56 | .297 | 1.27 | 10.6 | 1.2 | 7.4 | 23.2 | 27 | 12 | 12 | 2 | 3 | 19 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2.87 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 96 | 9 | 0 | 1 | 0 | 3.75 | .280 | 1.17 | 7.5 | 3.0 | 7.5 | 12.0 | 10 | 6 | 5 | 1 | 4 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.42 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 98 | 5 | 5 | 2 | 3 | 5.34 | .342 | 1.53 | 11.0 | 2.8 | 5.9 | 32.0 | 39 | 23 | 19 | 3 | 10 | 21 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 3.94 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 94 | 5 | 5 | 1 | 2 | 4.28 | .331 | 1.46 | 10.6 | 2.7 | 9.5 | 33.2 | 39 | 19 | 16 | 3 | 10 | 35 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 3.06 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 94 | 10 | 0 | 0 | 0 | 1.46 | .196 | 0.73 | 6.0 | 0.8 | 12.8 | 12.1 | 8 | 2 | 2 | 0 | 1 | 17 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0.42 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 97 | 6 | 0 | 0 | 0 | 3.18 | .292 | 1.24 | 10.8 | 1.8 | 3.6 | 5.2 | 6 | 2 | 2 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.40 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 94 | 4 | 4 | 1 | 2 | 6.98 | .383 | 1.86 | 12.3 | 4.7 | 7.6 | 19.1 | 26 | 16 | 15 | 6 | 10 | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 7.00 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 95 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 93 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |