| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 96 | 19 | 19 | 4 | 13 | 5.75 | .311 | 1.33 | 10.1 | 1.9 | 4.4 | 108.0 | 121 | 79 | 69 | 20 | 23 | 53 | 5 | 0 | 0 | 0 | 7 | 2 | 4 | 5.12 |
| SP | Skenes, P.Skenes, Paul >> | 22 | 2024 | R | 93 | 15 | 15 | 5 | 6 | 4.64 | .310 | 1.34 | 9.1 | 3.0 | 7.6 | 85.1 | 86 | 47 | 44 | 8 | 28 | 72 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 3.55 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 96 | 33 | 0 | 2 | 0 | 2.68 | .260 | 1.01 | 5.9 | 3.3 | 8.6 | 43.2 | 28 | 15 | 13 | 3 | 16 | 41 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.26 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 98 | 15 | 15 | 4 | 7 | 4.60 | .313 | 1.36 | 9.7 | 2.5 | 8.7 | 92.0 | 99 | 61 | 47 | 12 | 26 | 89 | 1 | 0 | 0 | 1 | 7 | 1 | 1 | 3.64 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 94 | 15 | 15 | 8 | 4 | 2.62 | .248 | 0.95 | 7.0 | 1.6 | 8.4 | 110.0 | 86 | 41 | 32 | 9 | 19 | 103 | 2 | 0 | 0 | 1 | 11 | 4 | 1 | 2.82 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 94 | 28 | 0 | 1 | 2 | 3.03 | .258 | 1.04 | 7.6 | 2.0 | 9.8 | 32.2 | 27 | 13 | 11 | 2 | 7 | 35 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 2.28 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 97 | 21 | 0 | 0 | 0 | 2.78 | .253 | 1.01 | 5.7 | 3.7 | 7.0 | 22.2 | 14 | 8 | 7 | 3 | 9 | 17 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.45 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 94 | 14 | 14 | 5 | 4 | 4.39 | .305 | 1.32 | 9.1 | 2.7 | 8.3 | 82.0 | 83 | 45 | 40 | 12 | 25 | 76 | 0 | 0 | 0 | 0 | 8 | 0 | 2 | 3.96 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 95 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 93 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |