| SP | Waddell, R.Waddell, Rube >> | 31 | 1907 | L | 97 | 7 | 7 | 2 | 5 | 5.36 | .355 | 1.65 | 11.8 | 3.2 | 5.4 | 45.1 | 59 | 28 | 27 | 3 | 16 | 27 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 3.73 |
| SP | Quintana, J.Quintana, Jose >> | 33 | 2022 | L | 72 | 7 | 7 | 1 | 2 | 5.21 | .321 | 1.32 | 8.5 | 3.3 | 5.2 | 38.0 | 36 | 22 | 22 | 5 | 14 | 22 | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 4.97 |
| SP | Verlander, J.Verlander, Justin >> | 31 | 2014 | R | 25 | 6 | 6 | 1 | 4 | 6.27 | .371 | 1.77 | 11.4 | 4.6 | 5.4 | 37.1 | 47 | 26 | 26 | 3 | 19 | 22 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.41 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 31 | 2011 | R | 93 | 12 | 0 | 0 | 2 | 3.27 | .250 | 1.00 | 9.0 | 0.0 | 9.0 | 11.0 | 11 | 4 | 4 | 0 | 0 | 11 | 0 | 8 | 1 | 0 | 0 | 0 | 0 | 1.00 |
| SU | Calero, K.Calero, Kiko >> | 30 | 2005 | R | 79 | 20 | 0 | 1 | 0 | 0.87 | .162 | 0.58 | 4.1 | 1.4 | 9.0 | 20.2 | 9 | 2 | 2 | 0 | 3 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.45 |
| RP | Martin, C.Martin, Chris >> | 38 | 2024 | R | 68 | 21 | 0 | 1 | 1 | 6.17 | .293 | 1.16 | 9.0 | 1.6 | 7.8 | 23.1 | 23 | 16 | 16 | 3 | 4 | 20 | 0 | 0 | 2 | 0 | 0 | 2 | 2 | 3.74 |
| RP | Robinson, J.Robinson, Jeff >> | 28 | 1988 | R | 65 | 12 | 0 | 2 | 0 | 3.32 | .296 | 1.26 | 9.0 | 2.4 | 5.2 | 19.0 | 19 | 7 | 7 | 3 | 5 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.68 |
| RP | Estevez, C.Estevez, Carlos >> | 30 | 2023 | R | 33 | 8 | 0 | 0 | 0 | 0.00 | .256 | 1.03 | 7.0 | 3.0 | 10.0 | 9.2 | 7 | 0 | 0 | 0 | 3 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.78 |
| SP | Mathewson, C.Mathewson, Christy >> | 31 | 1911 | R | 73 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | 0.0 | 0.0 | 0.0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |