| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 27 | 27 | 13 | 8 | 2.70 | .258 | 1.03 | 7.1 | 2.2 | 7.9 | 193.2 | 152 | 67 | 58 | 16 | 47 | 170 | 9 | 0 | 0 | 3 | 19 | 3 | 1 | 3.09 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 26 | 26 | 3 | 17 | 6.22 | .339 | 1.52 | 10.1 | 3.6 | 7.2 | 139.0 | 156 | 98 | 96 | 27 | 55 | 111 | 1 | 0 | 0 | 0 | 7 | 3 | 5 | 5.18 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 26 | 26 | 6 | 11 | 5.49 | .325 | 1.40 | 9.8 | 2.9 | 5.5 | 124.2 | 135 | 80 | 76 | 15 | 40 | 76 | 0 | 0 | 0 | 0 | 8 | 5 | 1 | 4.44 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 26 | 26 | 12 | 9 | 3.87 | .297 | 1.24 | 8.4 | 2.8 | 4.5 | 174.1 | 162 | 84 | 75 | 14 | 55 | 87 | 2 | 0 | 0 | 1 | 16 | 4 | 3 | 4.06 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 78 | 0 | 1 | 3 | 2.92 | .253 | 0.97 | 7.0 | 1.8 | 8.9 | 71.0 | 55 | 28 | 23 | 12 | 14 | 70 | 0 | 13 | 0 | 0 | 0 | 3 | 1 | 3.94 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 70 | 0 | 7 | 2 | 3.30 | .280 | 1.17 | 7.6 | 3.0 | 7.9 | 76.1 | 64 | 30 | 28 | 15 | 25 | 67 | 0 | 4 | 6 | 0 | 0 | 0 | 0 | 4.79 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 65 | 0 | 3 | 3 | 2.80 | .284 | 1.15 | 5.5 | 4.9 | 9.5 | 70.2 | 43 | 24 | 22 | 4 | 38 | 74 | 0 | 8 | 0 | 0 | 0 | 3 | 8 | 3.39 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 47 | 0 | 1 | 2 | 2.70 | .292 | 1.24 | 7.9 | 3.2 | 8.6 | 50.0 | 44 | 19 | 15 | 6 | 18 | 48 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 3.72 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 28 | 0 | 1 | 4 | 4.36 | .308 | 1.33 | 7.6 | 4.4 | 3.8 | 33.0 | 28 | 16 | 16 | 4 | 16 | 14 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.18 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 36 | 0 | 3 | 1 | 6.22 | .359 | 1.64 | 9.4 | 5.5 | 8.6 | 46.1 | 48 | 34 | 32 | 7 | 28 | 44 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 5.02 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 21 | 0 | 1 | 1 | 3.24 | .242 | 0.96 | 6.5 | 2.2 | 8.6 | 25.0 | 18 | 9 | 9 | 2 | 6 | 24 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.84 |