| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 95 | 27 | 27 | 14 | 6 | 3.20 | .288 | 1.19 | 6.8 | 3.9 | 7.8 | 171.1 | 129 | 63 | 61 | 13 | 75 | 148 | 1 | 0 | 0 | 0 | 18 | 4 | 4 | 3.64 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 26 | 26 | 17 | 5 | 2.42 | .245 | 0.95 | 6.8 | 1.8 | 5.3 | 200.2 | 150 | 56 | 54 | 18 | 41 | 117 | 10 | 0 | 0 | 6 | 19 | 4 | 1 | 3.68 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 26 | 26 | 15 | 3 | 2.64 | .253 | 1.01 | 6.8 | 2.4 | 5.4 | 197.2 | 148 | 63 | 58 | 18 | 52 | 118 | 6 | 0 | 0 | 3 | 20 | 1 | 2 | 3.80 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 26 | 26 | 10 | 8 | 4.67 | .310 | 1.33 | 8.2 | 3.8 | 7.8 | 150.1 | 136 | 79 | 78 | 28 | 64 | 130 | 0 | 0 | 0 | 0 | 10 | 3 | 3 | 5.03 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 60 | 25 | 25 | 12 | 7 | 3.64 | .314 | 1.34 | 7.4 | 4.7 | 4.5 | 163.0 | 134 | 68 | 66 | 11 | 85 | 81 | 2 | 0 | 0 | 1 | 17 | 5 | 0 | 4.54 |
| RP | Gagne, E.Gagne, Eric # >> | 27 | 2003 | R | 99 | 63 | 0 | 5 | 3 | 3.46 | .273 | 1.10 | 7.0 | 3.0 | 9.1 | 75.1 | 58 | 32 | 29 | 3 | 25 | 76 | 0 | 3 | 3 | 0 | 0 | 2 | 6 | 2.57 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 53 | 0 | 4 | 1 | 2.86 | .283 | 1.18 | 8.2 | 2.6 | 10.0 | 56.2 | 51 | 21 | 18 | 7 | 16 | 62 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 3.27 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 37 | 0 | 3 | 1 | 2.70 | .296 | 1.26 | 6.7 | 4.9 | 6.1 | 46.2 | 34 | 16 | 14 | 3 | 25 | 31 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.13 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 24 | 0 | 1 | 1 | 3.10 | .216 | 0.83 | 4.7 | 2.8 | 6.8 | 29.0 | 15 | 11 | 10 | 4 | 9 | 22 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 4.21 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 4 | 0 | 1 | 0 | 5.14 | .344 | 1.57 | 11.6 | 2.6 | 7.7 | 7.0 | 9 | 4 | 4 | 1 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 9 | 0 | 3 | 3 | 6.48 | .346 | 1.59 | 12.3 | 2.2 | 6.3 | 33.1 | 45 | 24 | 24 | 8 | 8 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.48 |
| CL | Kuo, H.Kuo, Hong-Chih † >> | 29 | 2010 | L | 91 | 58 | 0 | 2 | 5 | 4.13 | .309 | 1.27 | 6.4 | 5.1 | 8.7 | 56.2 | 40 | 26 | 26 | 5 | 32 | 54 | 0 | 29 | 3 | 0 | 0 | 4 | 2 | 4.16 |