| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 98 | 20 | 20 | 9 | 6 | 3.34 | .266 | 1.07 | 6.6 | 3.1 | 8.5 | 142.2 | 104 | 59 | 53 | 19 | 49 | 134 | 4 | 0 | 0 | 1 | 13 | 2 | 3 | 3.93 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 19 | 19 | 7 | 7 | 4.05 | .298 | 1.24 | 8.4 | 2.8 | 4.6 | 124.1 | 116 | 56 | 56 | 16 | 38 | 64 | 2 | 0 | 0 | 2 | 10 | 4 | 2 | 4.66 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 18 | 18 | 5 | 7 | 5.64 | .328 | 1.43 | 11.1 | 1.9 | 3.9 | 105.1 | 129 | 69 | 66 | 18 | 22 | 46 | 4 | 0 | 0 | 1 | 7 | 3 | 1 | 5.07 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 18 | 18 | 7 | 7 | 5.10 | .362 | 1.68 | 9.6 | 5.6 | 7.1 | 97.0 | 103 | 59 | 55 | 10 | 60 | 76 | 0 | 0 | 0 | 0 | 8 | 2 | 3 | 4.69 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 18 | 18 | 7 | 6 | 4.49 | .316 | 1.38 | 9.8 | 2.7 | 5.0 | 108.1 | 117 | 54 | 54 | 13 | 32 | 60 | 0 | 0 | 0 | 0 | 13 | 1 | 0 | 4.37 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 56 | 0 | 5 | 3 | 1.80 | .257 | 1.03 | 5.6 | 3.6 | 7.2 | 80.0 | 50 | 16 | 16 | 2 | 32 | 64 | 0 | 7 | 2 | 0 | 0 | 1 | 0 | 2.96 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 50 | 0 | 1 | 6 | 7.30 | .351 | 1.57 | 11.7 | 2.4 | 8.5 | 53.0 | 69 | 44 | 43 | 15 | 14 | 50 | 0 | 4 | 4 | 0 | 0 | 3 | 1 | 5.75 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 39 | 0 | 1 | 2 | 4.86 | .306 | 1.32 | 8.8 | 3.1 | 7.7 | 50.0 | 49 | 27 | 27 | 6 | 17 | 43 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 3.86 |
| RP | Fingers, R.Fingers, Rollie >> | 35 | 1981 | R | 52 | 27 | 0 | 0 | 2 | 5.24 | .304 | 1.25 | 10.3 | 1.1 | 4.8 | 34.1 | 39 | 21 | 20 | 9 | 4 | 18 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 5.91 |