| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 19 | 19 | 7 | 3 | 3.87 | .313 | 1.34 | 9.2 | 2.9 | 9.6 | 95.1 | 97 | 45 | 41 | 12 | 31 | 101 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 3.56 |
| SP | McLain, D.McLain, Denny † >> | 24 | 1968 | R | 78 | 18 | 18 | 11 | 5 | 3.33 | .294 | 1.25 | 8.7 | 2.5 | 5.3 | 132.1 | 128 | 50 | 49 | 14 | 37 | 78 | 3 | 0 | 0 | 0 | 12 | 0 | 0 | 4.04 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 17 | 16 | 6 | 5 | 4.47 | .307 | 1.30 | 8.8 | 3.0 | 5.5 | 100.2 | 98 | 50 | 50 | 8 | 33 | 61 | 0 | 0 | 0 | 0 | 9 | 3 | 2 | 3.90 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 37 | 0 | 2 | 4 | 3.57 | .321 | 1.42 | 8.0 | 4.9 | 9.5 | 35.1 | 31 | 16 | 14 | 3 | 19 | 37 | 0 | 20 | 4 | 0 | 0 | 0 | 1 | 3.63 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 43 | 0 | 2 | 3 | 5.01 | .364 | 1.72 | 10.3 | 5.3 | 9.0 | 41.1 | 47 | 25 | 23 | 7 | 24 | 41 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 4.98 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 47 | 0 | 4 | 0 | 1.73 | .212 | 0.81 | 5.0 | 2.3 | 4.8 | 52.0 | 29 | 11 | 10 | 2 | 13 | 28 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.17 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 40 | 0 | 3 | 2 | 4.84 | .342 | 1.50 | 9.8 | 3.9 | 11.1 | 35.1 | 38 | 20 | 19 | 5 | 15 | 43 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 3.86 |