| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 26 | 26 | 9 | 9 | 4.52 | .306 | 1.31 | 9.3 | 2.5 | 5.0 | 175.1 | 181 | 94 | 88 | 25 | 49 | 97 | 5 | 0 | 0 | 1 | 13 | 2 | 4 | 4.62 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 26 | 25 | 7 | 8 | 4.46 | .328 | 1.43 | 8.8 | 4.1 | 5.7 | 179.2 | 175 | 94 | 89 | 21 | 82 | 114 | 5 | 0 | 0 | 0 | 10 | 6 | 10 | 4.73 |
| CL | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 53 | 0 | 10 | 9 | 2.39 | .267 | 1.08 | 5.7 | 4.1 | 7.8 | 60.1 | 38 | 19 | 16 | 3 | 27 | 52 | 0 | 23 | 3 | 0 | 0 | 1 | 0 | 3.32 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 71 | 0 | 5 | 0 | 2.70 | .254 | 1.01 | 5.8 | 3.3 | 8.8 | 90.0 | 58 | 28 | 27 | 9 | 33 | 88 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 3.48 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 49 | 0 | 2 | 1 | 4.27 | .317 | 1.39 | 8.2 | 4.4 | 7.5 | 65.1 | 59 | 32 | 31 | 8 | 32 | 54 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.42 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 36 | 0 | 3 | 0 | 3.38 | .288 | 1.21 | 8.8 | 2.2 | 7.0 | 45.1 | 44 | 17 | 17 | 7 | 11 | 35 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.20 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 25 | 0 | 1 | 1 | 2.28 | .268 | 1.10 | 6.7 | 3.5 | 9.4 | 23.2 | 17 | 7 | 6 | 2 | 9 | 24 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 3.22 |