| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 24 | 24 | 9 | 10 | 3.31 | .282 | 1.14 | 7.7 | 2.6 | 8.7 | 196.0 | 168 | 78 | 72 | 21 | 56 | 190 | 8 | 0 | 0 | 2 | 14 | 7 | 1 | 3.42 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 23 | 23 | 11 | 7 | 4.71 | .304 | 1.27 | 9.2 | 2.3 | 5.2 | 179.2 | 183 | 97 | 94 | 16 | 45 | 103 | 9 | 0 | 0 | 1 | 10 | 7 | 3 | 3.88 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 23 | 23 | 8 | 9 | 5.63 | .320 | 1.41 | 9.4 | 3.4 | 5.5 | 124.2 | 129 | 84 | 78 | 21 | 47 | 76 | 0 | 0 | 0 | 0 | 7 | 0 | 2 | 5.11 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 23 | 23 | 12 | 8 | 4.17 | .304 | 1.28 | 8.9 | 2.7 | 6.1 | 179.0 | 177 | 85 | 83 | 22 | 53 | 122 | 12 | 0 | 0 | 2 | 12 | 4 | 1 | 4.19 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 21 | 21 | 8 | 8 | 4.22 | .328 | 1.44 | 9.4 | 3.6 | 4.8 | 162.0 | 170 | 82 | 76 | 14 | 64 | 86 | 5 | 0 | 0 | 0 | 10 | 3 | 4 | 4.30 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 53 | 0 | 7 | 5 | 2.34 | .252 | 1.01 | 7.4 | 1.7 | 7.7 | 69.1 | 57 | 19 | 18 | 10 | 13 | 59 | 0 | 8 | 3 | 0 | 0 | 0 | 3 | 3.74 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 40 | 0 | 3 | 2 | 3.61 | .253 | 1.01 | 7.7 | 1.5 | 7.5 | 47.1 | 40 | 22 | 19 | 7 | 8 | 39 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.79 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 23 | 0 | 3 | 0 | 3.60 | .292 | 1.24 | 4.7 | 6.5 | 8.3 | 25.0 | 13 | 10 | 10 | 0 | 18 | 23 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 3.32 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 18 | 0 | 2 | 2 | 3.72 | .333 | 1.50 | 10.4 | 3.3 | 6.2 | 19.1 | 22 | 10 | 8 | 1 | 7 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.42 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 2 | 0 | 0 | 0 | 0.00 | .375 | 1.80 | 9.0 | 18.0 | 0.0 | 1.2 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9.00 |