| SP | Johnson, W.Johnson, Walter # >> | 26 | 1913 | R | 95 | 23 | 23 | 11 | 8 | 3.42 | .267 | 1.08 | 8.1 | 1.6 | 4.7 | 171.0 | 154 | 68 | 65 | 18 | 31 | 89 | 6 | 0 | 0 | 1 | 14 | 2 | 3 | 3.91 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 22 | 22 | 5 | 9 | 4.96 | .341 | 1.53 | 10.2 | 3.6 | 4.9 | 139.2 | 158 | 82 | 77 | 14 | 55 | 76 | 4 | 0 | 0 | 1 | 10 | 4 | 0 | 4.49 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 22 | 22 | 7 | 6 | 6.92 | .361 | 1.68 | 11.1 | 4.1 | 4.6 | 106.2 | 131 | 84 | 82 | 19 | 48 | 54 | 0 | 0 | 0 | 0 | 7 | 2 | 1 | 5.73 |
| SP | Drysdale, D.Drysdale, Don # >> | 28 | 1964 | R | 59 | 22 | 22 | 6 | 9 | 5.93 | .344 | 1.54 | 11.5 | 2.4 | 5.0 | 129.0 | 165 | 88 | 85 | 19 | 34 | 72 | 3 | 0 | 0 | 0 | 7 | 4 | 3 | 4.68 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 65 | 0 | 7 | 3 | 3.91 | .313 | 1.31 | 8.4 | 3.5 | 8.4 | 78.1 | 73 | 39 | 34 | 12 | 30 | 73 | 0 | 3 | 3 | 0 | 0 | 4 | 0 | 4.44 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 53 | 0 | 4 | 3 | 3.60 | .286 | 1.17 | 7.1 | 3.5 | 7.2 | 60.0 | 47 | 27 | 24 | 5 | 23 | 48 | 0 | 3 | 3 | 0 | 0 | 2 | 4 | 3.73 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 72 | 0 | 3 | 4 | 5.14 | .311 | 1.34 | 9.6 | 2.4 | 8.2 | 56.0 | 60 | 32 | 32 | 6 | 15 | 51 | 0 | 3 | 2 | 0 | 0 | 1 | 2 | 3.43 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 49 | 0 | 1 | 4 | 3.38 | .333 | 1.47 | 7.3 | 6.1 | 10.6 | 58.2 | 47 | 26 | 22 | 7 | 39 | 68 | 0 | 5 | 2 | 0 | 0 | 2 | 0 | 4.34 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 55 | 27 | 0 | 3 | 4 | 2.93 | .291 | 1.23 | 9.0 | 2.3 | 3.3 | 27.2 | 27 | 10 | 9 | 4 | 7 | 10 | 0 | 8 | 1 | 0 | 0 | 0 | 0 | 4.96 |