| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 23 | 23 | 9 | 6 | 2.97 | .226 | 0.86 | 6.5 | 1.3 | 8.7 | 163.2 | 117 | 55 | 54 | 21 | 24 | 158 | 2 | 0 | 0 | 0 | 17 | 2 | 0 | 3.21 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 22 | 22 | 4 | 7 | 4.36 | .304 | 1.31 | 9.1 | 2.8 | 7.5 | 144.1 | 145 | 71 | 70 | 13 | 44 | 120 | 0 | 0 | 0 | 0 | 14 | 0 | 4 | 3.42 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 23 | 22 | 6 | 13 | 4.17 | .318 | 1.34 | 8.6 | 3.5 | 4.7 | 133.2 | 127 | 68 | 62 | 12 | 52 | 69 | 0 | 0 | 0 | 0 | 15 | 8 | 3 | 4.49 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 22 | 22 | 8 | 10 | 3.15 | .256 | 1.02 | 7.2 | 2.0 | 5.2 | 160.0 | 128 | 62 | 56 | 19 | 35 | 92 | 3 | 0 | 0 | 1 | 13 | 2 | 3 | 4.09 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 46 | 0 | 2 | 6 | 2.11 | .273 | 1.09 | 6.3 | 3.4 | 8.2 | 47.0 | 33 | 11 | 11 | 1 | 18 | 43 | 0 | 28 | 1 | 0 | 0 | 2 | 2 | 2.72 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 42 | 0 | 2 | 5 | 3.61 | .276 | 1.14 | 7.7 | 2.7 | 8.4 | 47.1 | 40 | 20 | 19 | 5 | 14 | 44 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 3.40 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 58 | 0 | 2 | 1 | 5.35 | .329 | 1.47 | 9.7 | 3.8 | 9.0 | 38.2 | 41 | 23 | 23 | 6 | 16 | 38 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.32 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 37 | 0 | 7 | 0 | 2.53 | .265 | 1.06 | 5.7 | 3.9 | 7.0 | 46.1 | 29 | 13 | 13 | 3 | 20 | 36 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.65 |