| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 97 | 23 | 23 | 11 | 11 | 3.42 | .257 | 1.01 | 7.3 | 1.8 | 8.6 | 181.2 | 147 | 71 | 69 | 14 | 37 | 173 | 12 | 0 | 0 | 2 | 13 | 5 | 3 | 2.79 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 22 | 22 | 6 | 7 | 6.19 | .359 | 1.66 | 11.7 | 3.4 | 4.2 | 107.2 | 139 | 78 | 74 | 13 | 40 | 50 | 0 | 0 | 0 | 0 | 6 | 2 | 0 | 4.82 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 22 | 22 | 4 | 15 | 6.22 | .351 | 1.62 | 11.4 | 3.2 | 3.7 | 140.1 | 178 | 106 | 97 | 15 | 49 | 58 | 1 | 0 | 0 | 0 | 7 | 1 | 1 | 4.64 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 55 | 0 | 5 | 3 | 2.37 | .249 | 0.99 | 6.8 | 2.2 | 8.6 | 83.2 | 63 | 26 | 22 | 5 | 20 | 79 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 2.60 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 57 | 0 | 4 | 2 | 3.58 | .306 | 1.31 | 9.2 | 2.5 | 9.3 | 78.0 | 80 | 31 | 31 | 7 | 22 | 81 | 0 | 7 | 2 | 0 | 0 | 1 | 0 | 2.97 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 45 | 0 | 2 | 1 | 2.68 | .257 | 1.02 | 5.8 | 3.3 | 9.3 | 57.0 | 37 | 23 | 17 | 6 | 21 | 59 | 0 | 6 | 0 | 0 | 0 | 1 | 1 | 3.46 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 37 | 0 | 2 | 1 | 3.40 | .300 | 1.28 | 6.6 | 4.9 | 9.7 | 53.0 | 39 | 29 | 20 | 3 | 29 | 57 | 0 | 1 | 1 | 0 | 0 | 0 | 5 | 3.23 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 1 | 0 | 0 | 9.00 | .400 | 2.00 | 14.4 | 3.6 | 7.2 | 5.0 | 8 | 5 | 5 | 1 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.20 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 27 | 0 | 5 | 3 | 4.78 | .352 | 1.59 | 10.3 | 4.0 | 3.5 | 49.0 | 56 | 26 | 26 | 7 | 22 | 19 | 0 | 1 | 3 | 0 | 0 | 2 | 0 | 5.55 |