| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 23 | 23 | 9 | 9 | 4.99 | .302 | 1.27 | 9.7 | 1.8 | 4.4 | 128.0 | 138 | 72 | 71 | 13 | 25 | 63 | 1 | 0 | 0 | 0 | 11 | 3 | 3 | 3.99 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 23 | 21 | 9 | 9 | 3.90 | .291 | 1.22 | 8.4 | 2.6 | 4.8 | 145.1 | 135 | 64 | 63 | 11 | 42 | 78 | 3 | 1 | 0 | 0 | 13 | 2 | 2 | 3.82 |
| SU | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 60 | 0 | 3 | 3 | 3.44 | .331 | 1.44 | 7.4 | 5.6 | 9.8 | 68.0 | 56 | 28 | 26 | 6 | 42 | 74 | 0 | 1 | 3 | 0 | 0 | 3 | 3 | 3.96 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 63 | 0 | 0 | 2 | 5.63 | .299 | 1.27 | 7.7 | 3.7 | 9.8 | 70.1 | 60 | 44 | 44 | 13 | 29 | 76 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 4.53 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 87 | 55 | 0 | 4 | 4 | 4.31 | .309 | 1.32 | 9.3 | 2.8 | 8.6 | 62.2 | 64 | 31 | 30 | 12 | 19 | 59 | 0 | 21 | 1 | 0 | 0 | 1 | 0 | 4.58 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 61 | 0 | 2 | 1 | 3.70 | .291 | 1.20 | 7.1 | 3.7 | 8.2 | 58.1 | 46 | 29 | 24 | 3 | 24 | 53 | 0 | 2 | 1 | 0 | 0 | 2 | 5 | 3.19 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 53 | 0 | 2 | 4 | 5.60 | .318 | 1.40 | 10.1 | 2.5 | 8.5 | 72.1 | 81 | 45 | 45 | 13 | 20 | 68 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.29 |