| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 98 | 20 | 20 | 11 | 6 | 3.53 | .290 | 1.22 | 7.9 | 3.1 | 8.8 | 158.0 | 138 | 63 | 62 | 16 | 54 | 154 | 6 | 0 | 0 | 1 | 11 | 2 | 2 | 3.43 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 20 | 20 | 5 | 9 | 5.57 | .308 | 1.32 | 9.1 | 2.9 | 7.2 | 116.1 | 117 | 74 | 72 | 23 | 37 | 93 | 0 | 0 | 0 | 0 | 8 | 1 | 2 | 4.96 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 20 | 20 | 5 | 13 | 5.47 | .340 | 1.53 | 10.7 | 3.1 | 4.7 | 135.0 | 160 | 91 | 82 | 15 | 47 | 70 | 6 | 0 | 0 | 1 | 5 | 2 | 3 | 4.50 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 63 | 20 | 20 | 6 | 8 | 5.04 | .310 | 1.34 | 9.8 | 2.3 | 4.5 | 141.0 | 153 | 82 | 79 | 15 | 36 | 71 | 5 | 0 | 0 | 0 | 7 | 1 | 2 | 4.16 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 51 | 0 | 1 | 2 | 3.42 | .301 | 1.29 | 5.9 | 5.7 | 8.0 | 79.0 | 52 | 30 | 30 | 6 | 50 | 70 | 0 | 8 | 2 | 0 | 0 | 0 | 0 | 4.11 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 42 | 0 | 6 | 1 | 2.78 | .297 | 1.25 | 9.0 | 2.3 | 4.8 | 58.1 | 58 | 28 | 18 | 4 | 15 | 31 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.66 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 36 | 0 | 1 | 3 | 4.54 | .315 | 1.38 | 7.1 | 5.6 | 9.7 | 37.2 | 29 | 20 | 19 | 1 | 23 | 40 | 0 | 6 | 1 | 0 | 0 | 0 | 5 | 3.05 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 27 | 0 | 3 | 2 | 5.16 | .360 | 1.65 | 8.7 | 6.5 | 12.1 | 29.2 | 28 | 17 | 17 | 1 | 21 | 39 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.03 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 56 | 20 | 0 | 2 | 2 | 8.71 | .374 | 1.74 | 9.5 | 6.8 | 8.1 | 20.2 | 21 | 20 | 20 | 4 | 15 | 18 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 6.20 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 13 | 1 | 1 | 2 | 5.68 | .380 | 1.79 | 10.4 | 5.7 | 4.3 | 19.0 | 22 | 14 | 12 | 2 | 12 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.47 |