| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 24 | 24 | 12 | 6 | 3.01 | .237 | 0.92 | 6.7 | 1.6 | 7.9 | 173.2 | 128 | 64 | 58 | 22 | 31 | 151 | 5 | 0 | 0 | 1 | 17 | 3 | 1 | 3.50 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 23 | 23 | 7 | 12 | 4.53 | .301 | 1.28 | 8.9 | 2.6 | 8.8 | 153.0 | 152 | 79 | 77 | 27 | 44 | 150 | 1 | 0 | 0 | 0 | 13 | 2 | 1 | 4.24 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 22 | 22 | 4 | 13 | 6.21 | .353 | 1.62 | 11.0 | 3.6 | 6.2 | 146.1 | 178 | 105 | 101 | 23 | 59 | 101 | 3 | 0 | 0 | 0 | 4 | 2 | 0 | 4.92 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 22 | 22 | 7 | 9 | 5.67 | .336 | 1.52 | 10.5 | 3.3 | 4.5 | 141.1 | 164 | 95 | 89 | 17 | 51 | 71 | 1 | 0 | 0 | 0 | 8 | 0 | 3 | 4.65 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 22 | 21 | 8 | 11 | 4.61 | .328 | 1.45 | 9.0 | 4.1 | 5.4 | 144.1 | 144 | 86 | 74 | 15 | 65 | 86 | 4 | 0 | 0 | 1 | 5 | 2 | 5 | 4.56 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 53 | 0 | 2 | 0 | 2.74 | .278 | 1.14 | 6.2 | 4.1 | 8.9 | 62.1 | 43 | 20 | 19 | 9 | 28 | 61 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 4.32 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 48 | 0 | 4 | 4 | 2.86 | .281 | 1.15 | 7.4 | 3.1 | 9.5 | 50.1 | 41 | 17 | 16 | 7 | 17 | 53 | 0 | 22 | 2 | 0 | 0 | 1 | 0 | 3.78 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 40 | 0 | 1 | 1 | 4.10 | .288 | 1.22 | 6.8 | 4.3 | 7.4 | 52.2 | 39 | 24 | 24 | 10 | 25 | 43 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.29 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 30 | 0 | 1 | 2 | 6.82 | .445 | 2.41 | 13.8 | 8.1 | 7.8 | 30.1 | 46 | 27 | 23 | 6 | 27 | 26 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 6.57 |