| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 15 | 15 | 6 | 4 | 4.04 | .294 | 1.20 | 8.1 | 2.7 | 10.8 | 89.0 | 80 | 42 | 40 | 7 | 27 | 107 | 0 | 0 | 0 | 0 | 9 | 4 | 0 | 2.66 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 15 | 15 | 5 | 4 | 6.59 | .351 | 1.61 | 10.1 | 4.3 | 9.4 | 71.0 | 80 | 56 | 52 | 17 | 34 | 74 | 0 | 0 | 0 | 0 | 5 | 1 | 3 | 5.51 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 37 | 0 | 3 | 1 | 5.40 | .335 | 1.49 | 9.2 | 4.2 | 7.2 | 45.0 | 46 | 27 | 27 | 11 | 21 | 36 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 6.04 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 30 | 0 | 4 | 0 | 5.50 | .307 | 1.33 | 9.7 | 2.4 | 10.9 | 37.2 | 40 | 23 | 23 | 2 | 10 | 45 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.08 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 25 | 0 | 1 | 1 | 5.40 | .317 | 1.39 | 9.0 | 3.8 | 9.0 | 31.2 | 31 | 21 | 19 | 3 | 13 | 31 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 3.52 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 67 | 26 | 0 | 4 | 1 | 5.94 | .355 | 1.65 | 11.8 | 3.3 | 9.3 | 36.1 | 47 | 27 | 24 | 9 | 13 | 37 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 5.28 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 5 | 0 | 1 | 1 | 5.00 | .386 | 1.89 | 10.0 | 7.0 | 6.0 | 9.0 | 10 | 5 | 5 | 1 | 7 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.44 |