| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 6 | 6 | 2 | 3 | 4.58 | .317 | 1.39 | 8.8 | 3.9 | 9.7 | 37.1 | 36 | 23 | 19 | 4 | 16 | 40 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.54 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 5 | 5 | 1 | 3 | 10.08 | .370 | 1.76 | 13.0 | 2.9 | 9.7 | 25.0 | 36 | 28 | 28 | 7 | 8 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.44 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 5 | 5 | 3 | 1 | 4.50 | .338 | 1.53 | 9.9 | 3.9 | 6.3 | 30.0 | 33 | 15 | 15 | 2 | 13 | 21 | 1 | 0 | 0 | 1 | 3 | 0 | 1 | 3.77 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 5 | 5 | 1 | 3 | 4.45 | .307 | 1.33 | 9.8 | 2.3 | 3.4 | 32.1 | 35 | 20 | 16 | 6 | 8 | 12 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 5.44 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 13 | 0 | 1 | 2 | 6.11 | .303 | 1.25 | 9.0 | 2.6 | 8.5 | 17.2 | 17 | 13 | 12 | 3 | 5 | 16 | 0 | 4 | 0 | 0 | 0 | 1 | 1 | 4.47 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 17 | 0 | 1 | 1 | 3.47 | .271 | 1.11 | 5.5 | 4.7 | 7.8 | 23.1 | 14 | 9 | 9 | 2 | 12 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.96 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 13 | 0 | 0 | 0 | 3.00 | .239 | 0.94 | 4.5 | 4.0 | 6.5 | 18.0 | 9 | 7 | 6 | 1 | 8 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.61 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 14 | 0 | 0 | 0 | 4.15 | .297 | 1.27 | 9.0 | 2.6 | 8.5 | 17.1 | 17 | 10 | 8 | 6 | 5 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.59 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 12 | 0 | 0 | 1 | 3.71 | .346 | 1.59 | 10.1 | 4.2 | 5.8 | 17.0 | 19 | 7 | 7 | 2 | 8 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.65 |