| SP | deGrom, J.deGrom, Jacob $$ >> | 33 | 2021 | R | 100 | 34 | 34 | 12 | 11 | 4.06 | .294 | 1.23 | 8.2 | 2.8 | 9.3 | 215.0 | 197 | 102 | 97 | 26 | 67 | 223 | 1 | 0 | 0 | 1 | 14 | 4 | 0 | 3.49 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 85 | 33 | 33 | 9 | 15 | 5.54 | .318 | 1.38 | 9.9 | 2.6 | 8.3 | 201.1 | 220 | 130 | 124 | 42 | 58 | 185 | 2 | 0 | 0 | 1 | 12 | 3 | 6 | 4.79 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 32 | 32 | 11 | 12 | 5.72 | .362 | 1.69 | 11.0 | 4.2 | 5.2 | 200.0 | 244 | 138 | 127 | 38 | 93 | 116 | 1 | 0 | 0 | 1 | 10 | 3 | 6 | 5.75 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 32 | 32 | 8 | 13 | 4.91 | .333 | 1.49 | 9.9 | 3.5 | 4.9 | 196.0 | 215 | 119 | 107 | 28 | 77 | 106 | 4 | 0 | 0 | 3 | 14 | 2 | 5 | 4.98 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 80 | 0 | 5 | 6 | 3.26 | .284 | 1.18 | 6.4 | 4.2 | 10.2 | 94.0 | 67 | 37 | 34 | 7 | 44 | 107 | 0 | 26 | 4 | 0 | 0 | 1 | 9 | 3.13 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 104 | 0 | 5 | 8 | 3.53 | .272 | 1.12 | 6.4 | 3.7 | 10.2 | 132.2 | 94 | 54 | 52 | 17 | 54 | 149 | 0 | 0 | 4 | 0 | 0 | 1 | 6 | 3.67 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 92 | 0 | 5 | 8 | 3.87 | .299 | 1.26 | 7.9 | 3.4 | 6.0 | 107.0 | 94 | 50 | 46 | 12 | 41 | 71 | 0 | 3 | 2 | 0 | 0 | 2 | 0 | 4.34 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 69 | 0 | 6 | 0 | 3.31 | .273 | 1.13 | 7.4 | 2.8 | 7.7 | 81.2 | 67 | 32 | 30 | 13 | 25 | 69 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.31 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 62 | 0 | 2 | 2 | 3.72 | .322 | 1.43 | 8.3 | 4.6 | 7.7 | 75.0 | 69 | 33 | 31 | 10 | 38 | 64 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 4.55 |