| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 33 | 33 | 11 | 9 | 3.30 | .260 | 1.03 | 7.1 | 2.2 | 7.6 | 213.0 | 167 | 80 | 78 | 26 | 52 | 179 | 3 | 0 | 0 | 2 | 21 | 5 | 2 | 3.71 |
| SP | Arrieta, J.Arrieta, Jake # $ >> | 29 | 2015 | R | 92 | 33 | 33 | 7 | 13 | 4.52 | .326 | 1.43 | 9.0 | 3.9 | 7.1 | 191.1 | 191 | 104 | 96 | 19 | 83 | 150 | 0 | 0 | 0 | 0 | 16 | 4 | 4 | 4.09 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 86 | 32 | 32 | 9 | 11 | 4.16 | .291 | 1.20 | 8.9 | 2.0 | 3.9 | 197.0 | 194 | 92 | 91 | 16 | 43 | 85 | 6 | 0 | 0 | 2 | 18 | 6 | 3 | 3.94 |
| SP | Johnson, R.Johnson, Randy † # >> | 41 | 2004 | L | 83 | 31 | 31 | 20 | 7 | 2.77 | .256 | 1.01 | 7.1 | 2.0 | 7.0 | 204.1 | 161 | 63 | 63 | 22 | 46 | 159 | 3 | 0 | 0 | 0 | 23 | 4 | 2 | 3.58 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 31 | 30 | 13 | 11 | 3.64 | .297 | 1.24 | 7.1 | 4.1 | 7.8 | 188.0 | 149 | 77 | 76 | 20 | 85 | 162 | 1 | 0 | 0 | 0 | 20 | 4 | 4 | 4.08 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 78 | 0 | 3 | 6 | 2.80 | .311 | 1.36 | 8.2 | 4.0 | 8.9 | 90.0 | 82 | 29 | 28 | 11 | 40 | 89 | 0 | 10 | 1 | 0 | 0 | 0 | 4 | 3.94 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 53 | 0 | 7 | 4 | 2.52 | .235 | 0.89 | 6.9 | 1.2 | 11.0 | 60.2 | 46 | 17 | 17 | 8 | 8 | 73 | 0 | 10 | 4 | 0 | 0 | 2 | 2 | 2.80 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 23 | 0 | 2 | 1 | 4.00 | .308 | 1.33 | 6.7 | 5.3 | 8.0 | 27.0 | 20 | 12 | 12 | 2 | 16 | 24 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.96 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 49 | 32 | 0 | 5 | 0 | 2.99 | .281 | 1.16 | 6.8 | 3.7 | 8.7 | 78.1 | 59 | 27 | 26 | 8 | 32 | 75 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.68 |