| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 20 | 20 | 10 | 6 | 3.89 | .283 | 1.17 | 8.0 | 2.5 | 7.8 | 122.2 | 109 | 54 | 53 | 12 | 34 | 106 | 1 | 0 | 0 | 0 | 10 | 2 | 4 | 3.43 |
| SP | Leonard, D.Leonard, Dutch $ >> | 22 | 1914 | L | 91 | 19 | 19 | 9 | 4 | 2.75 | .266 | 1.07 | 7.2 | 2.6 | 4.8 | 127.2 | 101 | 40 | 39 | 13 | 36 | 68 | 2 | 0 | 0 | 1 | 16 | 2 | 2 | 4.16 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 85 | 19 | 19 | 10 | 2 | 3.79 | .263 | 1.06 | 7.4 | 2.1 | 4.0 | 126.0 | 104 | 54 | 53 | 11 | 30 | 56 | 2 | 0 | 0 | 1 | 10 | 1 | 0 | 3.98 |
| SP | Guidry, R.Guidry, Ron † >> | 28 | 1978 | L | 77 | 19 | 19 | 11 | 7 | 3.42 | .286 | 1.18 | 7.2 | 3.4 | 6.1 | 155.1 | 124 | 63 | 59 | 10 | 59 | 105 | 11 | 0 | 0 | 3 | 12 | 4 | 3 | 3.70 |
| SP | McDowell, S.McDowell, Sam >> | 26 | 1968 | L | 45 | 18 | 18 | 10 | 5 | 2.97 | .274 | 1.12 | 6.6 | 3.5 | 7.1 | 148.1 | 108 | 50 | 49 | 16 | 58 | 117 | 12 | 0 | 0 | 1 | 13 | 2 | 5 | 4.04 |
| RP | Kimbrel, C.Kimbrel, Craig † $ >> | 24 | 2012 | R | 100 | 45 | 0 | 5 | 1 | 1.66 | .247 | 0.98 | 5.4 | 3.5 | 10.1 | 65.0 | 39 | 12 | 12 | 2 | 25 | 73 | 0 | 5 | 2 | 0 | 0 | 0 | 4 | 2.31 |
| RP | Miller, A.Miller, Andrew $ >> | 29 | 2014 | L | 88 | 35 | 0 | 3 | 0 | 1.57 | .169 | 0.61 | 3.7 | 1.8 | 9.6 | 46.0 | 19 | 8 | 8 | 3 | 9 | 49 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 2.30 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 26 | 0 | 2 | 2 | 2.17 | .336 | 1.52 | 9.0 | 4.7 | 7.8 | 29.0 | 29 | 7 | 7 | 2 | 15 | 25 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.72 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 15 | 0 | 1 | 1 | 3.44 | .295 | 1.25 | 6.5 | 5.0 | 11.0 | 18.1 | 13 | 7 | 7 | 1 | 10 | 22 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.94 |