| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 21 | 21 | 5 | 7 | 5.46 | .321 | 1.39 | 10.2 | 2.3 | 7.7 | 122.0 | 138 | 75 | 74 | 17 | 31 | 105 | 3 | 0 | 0 | 1 | 9 | 4 | 0 | 3.95 |
| SP | Gibson, B.Gibson, Bob # >> | 33 | 1968 | R | 92 | 20 | 19 | 6 | 8 | 3.99 | .293 | 1.22 | 8.6 | 2.4 | 5.1 | 119.2 | 114 | 58 | 53 | 17 | 32 | 67 | 6 | 0 | 0 | 0 | 10 | 3 | 1 | 4.61 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 19 | 19 | 8 | 4 | 3.66 | .315 | 1.36 | 9.2 | 3.0 | 8.8 | 125.1 | 128 | 57 | 51 | 12 | 42 | 122 | 1 | 0 | 0 | 0 | 14 | 3 | 4 | 3.38 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 19 | 19 | 6 | 7 | 5.52 | .342 | 1.53 | 10.8 | 3.0 | 5.1 | 104.1 | 125 | 66 | 64 | 18 | 35 | 59 | 2 | 0 | 0 | 1 | 8 | 3 | 0 | 5.21 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 50 | 0 | 2 | 6 | 2.96 | .322 | 1.39 | 7.8 | 4.8 | 8.3 | 54.2 | 47 | 18 | 18 | 3 | 29 | 50 | 0 | 24 | 6 | 0 | 0 | 2 | 0 | 3.59 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 54 | 0 | 3 | 5 | 5.10 | .331 | 1.47 | 8.4 | 4.8 | 10.5 | 60.0 | 56 | 35 | 34 | 7 | 32 | 70 | 0 | 1 | 5 | 0 | 0 | 1 | 0 | 3.83 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 54 | 0 | 4 | 2 | 2.93 | .268 | 1.07 | 7.5 | 2.2 | 8.6 | 73.2 | 61 | 26 | 24 | 7 | 18 | 70 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 3.15 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 41 | 0 | 2 | 1 | 4.23 | .309 | 1.34 | 7.4 | 4.9 | 9.6 | 44.2 | 36 | 24 | 21 | 4 | 24 | 47 | 0 | 0 | 2 | 0 | 0 | 0 | 3 | 3.68 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 38 | 0 | 7 | 2 | 4.91 | .313 | 1.36 | 7.1 | 5.4 | 7.9 | 47.2 | 37 | 26 | 26 | 3 | 28 | 41 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 3.87 |