| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 27 | 27 | 8 | 13 | 4.20 | .291 | 1.21 | 8.9 | 2.0 | 8.8 | 197.1 | 195 | 97 | 92 | 27 | 44 | 192 | 5 | 0 | 0 | 2 | 16 | 4 | 3 | 3.56 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 82 | 26 | 26 | 12 | 9 | 3.57 | .282 | 1.15 | 8.1 | 2.3 | 4.1 | 194.1 | 174 | 81 | 77 | 15 | 49 | 89 | 7 | 0 | 0 | 4 | 14 | 6 | 2 | 3.94 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 25 | 25 | 5 | 10 | 5.88 | .337 | 1.49 | 10.7 | 2.7 | 4.9 | 162.1 | 193 | 116 | 106 | 24 | 49 | 89 | 1 | 0 | 0 | 0 | 7 | 5 | 2 | 4.83 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 25 | 25 | 9 | 10 | 4.33 | .339 | 1.52 | 9.1 | 4.7 | 4.2 | 149.2 | 150 | 79 | 72 | 24 | 77 | 70 | 0 | 0 | 0 | 0 | 14 | 3 | 1 | 5.77 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 24 | 24 | 12 | 6 | 4.29 | .333 | 1.48 | 8.2 | 5.2 | 4.3 | 149.0 | 135 | 71 | 71 | 12 | 86 | 71 | 0 | 0 | 0 | 0 | 16 | 2 | 0 | 4.87 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 71 | 0 | 6 | 6 | 4.36 | .305 | 1.30 | 9.1 | 2.7 | 9.7 | 88.2 | 89 | 45 | 43 | 14 | 26 | 95 | 0 | 3 | 3 | 0 | 0 | 2 | 2 | 3.86 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 61 | 0 | 6 | 1 | 3.03 | .268 | 1.10 | 8.2 | 1.8 | 8.3 | 77.1 | 70 | 26 | 26 | 6 | 15 | 71 | 0 | 13 | 1 | 0 | 0 | 0 | 1 | 2.75 |
| RP | Dotel, O.Dotel, Octavio # >> | 29 | 2002 | R | 69 | 48 | 0 | 5 | 4 | 4.10 | .350 | 1.55 | 9.2 | 4.9 | 8.8 | 48.1 | 49 | 25 | 22 | 2 | 26 | 47 | 0 | 7 | 1 | 0 | 0 | 3 | 3 | 3.40 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 11 | 1 | 3 | 1 | 2.10 | .274 | 1.07 | 6.6 | 3.0 | 3.9 | 30.0 | 22 | 7 | 7 | 1 | 10 | 13 | 0 | 0 | 2 | 0 | 1 | 2 | 2 | 3.77 |