| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 20 | 20 | 9 | 5 | 3.48 | .270 | 1.10 | 7.6 | 2.4 | 9.8 | 137.0 | 115 | 54 | 53 | 16 | 36 | 149 | 0 | 0 | 0 | 0 | 13 | 1 | 0 | 3.15 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 20 | 20 | 6 | 9 | 4.73 | .313 | 1.33 | 9.5 | 2.5 | 4.6 | 148.1 | 157 | 80 | 78 | 13 | 41 | 76 | 3 | 0 | 0 | 0 | 8 | 5 | 4 | 4.05 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 19 | 19 | 9 | 7 | 3.20 | .288 | 1.21 | 8.1 | 2.8 | 6.0 | 157.2 | 141 | 59 | 56 | 11 | 49 | 105 | 9 | 0 | 0 | 2 | 11 | 1 | 3 | 3.53 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 19 | 19 | 6 | 11 | 4.61 | .325 | 1.42 | 9.6 | 3.3 | 5.7 | 130.2 | 138 | 71 | 67 | 19 | 48 | 83 | 4 | 0 | 0 | 1 | 9 | 3 | 5 | 4.80 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 50 | 0 | 2 | 4 | 3.50 | .285 | 1.20 | 7.7 | 3.1 | 8.4 | 64.1 | 55 | 27 | 25 | 10 | 22 | 60 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 4.19 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 41 | 0 | 1 | 2 | 3.20 | .262 | 1.07 | 7.9 | 1.8 | 7.2 | 50.2 | 44 | 20 | 18 | 7 | 10 | 40 | 0 | 4 | 3 | 0 | 0 | 0 | 1 | 3.82 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 31 | 0 | 6 | 4 | 3.57 | .325 | 1.42 | 9.5 | 3.3 | 4.9 | 35.1 | 37 | 15 | 14 | 4 | 13 | 19 | 0 | 3 | 4 | 0 | 0 | 1 | 0 | 4.60 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 54 | 17 | 0 | 0 | 0 | 4.82 | .356 | 1.55 | 8.0 | 6.5 | 11.5 | 18.2 | 16 | 11 | 10 | 0 | 13 | 23 | 0 | 1 | 0 | 0 | 0 | 2 | 4 | 2.94 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 7 | 0 | 0 | 1 | 4.91 | .353 | 1.64 | 9.0 | 6.4 | 6.4 | 7.1 | 7 | 4 | 4 | 2 | 5 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.43 |