| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 30 | 30 | 10 | 11 | 4.66 | .297 | 1.23 | 9.3 | 1.8 | 9.8 | 183.2 | 189 | 98 | 95 | 34 | 37 | 199 | 0 | 0 | 0 | 0 | 13 | 7 | 0 | 3.96 |
| SP | Peralta, F.Peralta, Freddy # >> | 29 | 2025 | R | 88 | 29 | 29 | 8 | 15 | 4.22 | .294 | 1.22 | 8.4 | 2.6 | 10.5 | 153.2 | 143 | 78 | 72 | 22 | 45 | 178 | 0 | 0 | 0 | 0 | 12 | 4 | 4 | 3.50 |
| SP | Mahle, T.Mahle, Tyler # >> | 30 | 2025 | R | 72 | 29 | 29 | 5 | 13 | 5.52 | .328 | 1.44 | 9.1 | 3.9 | 8.4 | 150.0 | 151 | 102 | 92 | 19 | 65 | 140 | 0 | 0 | 0 | 0 | 8 | 4 | 0 | 4.16 |
| SP | Singer, B.Singer, Brady >> | 28 | 2025 | R | 63 | 31 | 28 | 4 | 9 | 5.18 | .376 | 1.79 | 11.9 | 4.3 | 8.3 | 120.0 | 158 | 81 | 69 | 20 | 57 | 111 | 0 | 1 | 0 | 0 | 4 | 2 | 3 | 4.79 |
| RP | Rodríguez, R.Rodríguez, Randy >> | 25 | 2025 | R | 94 | 84 | 0 | 10 | 4 | 4.81 | .310 | 1.32 | 7.4 | 4.5 | 11.0 | 97.1 | 80 | 53 | 52 | 8 | 48 | 119 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 3.20 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 88 | 92 | 0 | 1 | 3 | 3.72 | .294 | 1.19 | 5.9 | 4.9 | 10.8 | 96.2 | 63 | 40 | 40 | 13 | 52 | 115 | 0 | 1 | 3 | 0 | 0 | 6 | 0 | 4.18 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 81 | 98 | 0 | 1 | 6 | 3.01 | .304 | 1.27 | 7.8 | 3.8 | 8.0 | 74.2 | 64 | 28 | 25 | 6 | 31 | 66 | 0 | 2 | 3 | 0 | 0 | 3 | 3 | 3.65 |
| RP | Williams, D.Williams, Devin >> | 30 | 2025 | R | 74 | 86 | 0 | 4 | 3 | 4.86 | .319 | 1.33 | 7.0 | 5.0 | 11.2 | 83.1 | 65 | 45 | 45 | 12 | 46 | 103 | 0 | 8 | 5 | 0 | 0 | 6 | 5 | 4.28 |
| RP | Coulombe, D.Coulombe, Daniel >> | 35 | 2025 | L | 60 | 87 | 0 | 5 | 0 | 3.08 | .311 | 1.32 | 8.3 | 3.6 | 10.2 | 73.0 | 67 | 25 | 25 | 11 | 29 | 83 | 0 | 6 | 1 | 0 | 0 | 3 | 3 | 4.00 |
| RP | Stewart, B.Stewart, Brock >> | 33 | 2025 | R | 54 | 76 | 0 | 2 | 2 | 3.52 | .299 | 1.26 | 7.9 | 3.4 | 10.2 | 84.1 | 74 | 34 | 33 | 10 | 32 | 95 | 0 | 7 | 2 | 0 | 0 | 2 | 2 | 3.50 |